Acifix 20

80.00৳ Strip

  • Purpose: Treats active duodenal and gastric ulcers, GERD, Zollinger-Ellison Syndrome, and aids in Helicobacter pylori eradication.
  • Action: Reduces gastric acid secretion to alleviate severe gastrointestinal symptoms.
  • Usage: Take one tablet daily before meals.
  • Consultation: Follow your healthcare provider’s dosing and usage instructions for best results.
Brand

Beximco Pharmaceuticals Ltd

Generics

Rabeprazole Sodium

Type

Capsule

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Description

Indications

Acifix Gastro-resistant Tablets are designed to address various gastrointestinal conditions, including:

  • Active duodenal ulcers
  • Active benign gastric ulcers
  • Symptomatic erosive or ulcerative gastroesophageal reflux disease (GERD)
  • Long-term management of GERD (GERD Maintenance)
  • Symptomatic treatment for moderate to severe GERD
  • Zollinger-Ellison Syndrome
  • Eradication of Helicobacter pylori in peptic ulcer disease, in conjunction with appropriate antibacterial treatments

Pharmacology

Acifix contains Rabeprazole, a potent proton-pump inhibitor. Rabeprazole effectively reduces gastric acid secretion by blocking the H+/K+-ATPase enzyme on the gastric parietal cell surface, which is crucial for acid production.

Dosage

  • Active Duodenal and Benign Gastric Ulcers: 20 mg once daily in the morning. Most patients see healing within four weeks for duodenal ulcers and six weeks for gastric ulcers. Extended treatment may be necessary for some patients.
  • Erosive or Ulcerative GERD: 20 mg once daily for four to eight weeks.
  • GERD Maintenance: 20 mg or 10 mg once daily, adjusted based on patient response.
  • Severe Symptomatic GERD: 10 mg once daily, with an option to adjust dosage if symptoms persist. Once controlled, symptoms can be managed with on-demand dosing.
  • Pediatric GERD Treatment (Ages 1-11):
    • <15 kg: 5 mg once daily for 12 weeks, with a potential increase to 10 mg if needed.
    • ≥15 kg: 10 mg once daily for 12 weeks.
  • Zollinger-Ellison Syndrome: Start with 60 mg once daily, potentially increasing to 120 mg/day based on patient needs. Higher doses may require split dosing.
  • Helicobacter pylori Eradication: Combine 20 mg of Rabeprazole twice daily with 500 mg of clarithromycin and 1 g of amoxicillin twice daily for 7 days.

Administration

Take Acifix tablets in the morning before meals. Swallow tablets whole—do not chew or crush. Adhering to this regimen improves treatment compliance.

Interactions

Acifix may interact with pH-dependent compounds. Co-administration with ketoconazole or itraconazole may reduce antifungal levels, and it should not be used with atazanavir due to pH-dependence. No interaction with liquid antacids was observed.

Contraindications

Do not use Acifix if you have hypersensitivity to Rabeprazole or any excipients. It is contraindicated during pregnancy and breastfeeding.

Side Effects

Common side effects include headache, diarrhea, abdominal pain, nausea, constipation, dry mouth, appetite changes, muscle pain, drowsiness, and dizziness. Serious effects are rare but may include kidney issues, liver damage, and bone fractures.

Pregnancy & Lactation

Rated FDA category ‘C’ for pregnancy. Animal studies show no harm, but adequate studies in pregnant women are lacking. Rabeprazole may be excreted in breast milk; consider the benefits and risks if nursing.

Precautions & Warnings

  • Exclude malignancy before starting treatment.
  • Long-term use may increase fracture risk; ensure adequate vitamin D and calcium intake.
  • Monitor for hypomagnesaemia and vitamin B12 deficiency.
  • Use with caution in patients with severe hepatic impairment.

Use in Special Populations

No dosage adjustment is needed for renal or hepatic impairment. Not recommended for children due to insufficient safety data.

Overdose Effects

Symptoms of overdose are generally minimal. There is no specific antidote. Treatment should be symptomatic and supportive.

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Store below 30°C, away from light and moisture. Keep out of reach of children.

Chemical Structure

  • Molecular Formula: C18H21N3O3S
  • Structure: Rabeprazole Sodium

FAQs

  • What is Acifix 20 mg Capsule? Acifix is a proton pump inhibitor that reduces gastric acid production.
  • What is it used for? It treats ulcers, GERD, Zollinger-Ellison Syndrome, and aids in Helicobacter pylori eradication.
  • What are the side effects? Common side effects include diarrhea, constipation, and nausea. Rare serious side effects include kidney problems and bone fractures.
  • How should I take it? Take one tablet daily with food. Do not exceed the prescribed dose.
  • Can it be used during pregnancy or breastfeeding? Not recommended. Consult your doctor for advice.
  • What if I overdose? Seek medical attention immediately. Overdose effects are typically mild.
  • How long should I use it? Treatment duration varies by condition. For GERD, it’s usually 4-8 weeks.
  • Any additional advice? Maintain hydration and a high-fiber diet to mitigate common side effects like dry mouth and constipation. Consult your doctor if you experience severe symptoms or have concerns about bone health.

Quick Tips

  • Acifix is generally well-tolerated and effective.
  • Avoid late-night meals.
  • Consult your doctor if symptoms persist or if you experience any unusual side effects.
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