Remac PFS

Indications

Remac serves as an effective treatment for various conditions, including:

• Acute exacerbation of chronic bronchitis in adults caused by bacterial infection.
• Acute maxillary sinusitis.
• Community-acquired pneumonia.
• Pharyngitis or tonsillitis.
• Uncomplicated skin and skin structure infections.
• Acute otitis media in pediatric patients.
• Treatment and prevention of disseminated mycobacterial infections.
• Helicobacter pylori infection and duodenal ulcer disease in adults.

Pharmacology

Remac’s active ingredient, clarithromycin, operates by impeding protein synthesis in susceptible organisms, primarily by binding to the donor site on the 50S subunit of the bacterial ribosome. This action prevents translocation to the site, effectively inhibiting bacterial growth. It exhibits potency against most Gram-positive bacteria, Chlamydia, certain Gram-negative bacteria, and Mycoplasmas. Moreover, Remac demonstrates enhanced acid stability compared to erythromycin, resulting in improved tolerance.

Dosage & Administration

For adults, dosage recommendations vary depending on the condition being treated. Dosages range from 250 mg to 500 mg every 12 hours for durations typically spanning 7 to 14 days. Pediatric dosages are weight-based and administered every 12 hours.

Interaction

Remac interacts adversely with certain medications, including HMG-CoA reductase inhibitors, gastroprokinetic agents, ergot alkaloids, antipsychotics, and anti-gout agents. Additionally, caution is advised when using antiarrhythmics concurrently.

Contraindications

Remac is contraindicated in patients with known hypersensitivity to clarithromycin, erythromycin, or any macrolide antibacterial drugs.

Side Effects

While generally well-tolerated, common side effects of Remac include nausea, vomiting, diarrhea, abdominal pain, stomatitis, glossitis, headache, and allergic reactions. Transient central nervous system side effects may also occur.

Pregnancy & Lactation

The use of Remac during pregnancy and lactation is not recommended due to limited data on its safety in these populations.

Precautions & Warnings

Special precautions should be taken in patients with QT prolongation, ventricular arrhythmia, hypokalemia, hypomagnesemia, significant bradycardia, or receiving certain antiarrhythmic medications. Monitoring for adverse reactions such as hepatitis and Clostridium difficile associated diarrhea is advised.

Use in Special Populations

Remac’s safety and efficacy have been established for various pediatric conditions, but caution should be exercised in children under certain age thresholds.

Overdose Effects

Overdose of Remac may lead to gastrointestinal symptoms and should be managed with supportive measures.

Therapeutic Class

Remac belongs to the macrolide class of antibiotics.

Storage Conditions

Store Remac in a cool, dry place, shielded from light and moisture. Reconstituted suspension should be used within specified timeframes and kept out of reach of children.