Nightus 3

Indications

Nightus is prescribed for a variety of conditions including:

• Emotional disturbances such as acute tension, anxiety states, and difficulties in interpersonal contact.
• Functional disturbances in cardiovascular and respiratory systems like pseudoangina, tachycardia, and emotiogenic hypertension.
• Gastrointestinal tract disturbances including irritable bowel syndrome and epigastric pain.
• Urinary tract disturbances like frequency and irritable bladder.
• Psychosomatic disorders such as psychogenic headache and asthma.
• Emotional reactions to chronic organic diseases.

Pharmacology

Bromazepam, a potent psychotropic agent, selectively reduces tension and anxiety at lower doses and exhibits sedative and muscle-relaxant properties at higher doses. It acts by binding to the GABA-A receptor, enhancing its inhibitory effects without affecting other neurotransmitters.

Dosage

• Standard dosage: Typically 1.5-3 mg up to three times daily for outpatient therapy, starting with lower doses and gradually increasing.
• Severe cases: 6-12 mg 2 or 3 times daily, usually in hospital settings, not exceeding 8-12 weeks of treatment.
• Elderly and debilitated patients: Require lower doses due to impaired hepatic function.
• Children: Generally not recommended, but if necessary, dosage adjusted based on body weight.

Administration

Nightus tablets are administered orally.

Interaction

Nightus may enhance sedative effects when combined with other centrally active drugs such as antidepressants, hypnotics, and antipsychotics. Cimetidine may prolong its elimination half-life. Alcohol intake should be avoided due to intensified sedative effects.

Contraindications

Bromazepam should not be used in patients with hypersensitivity to bromazepam, severe respiratory or hepatic insufficiency, or sleep apnea syndrome.

Side Effects

Common side effects include fatigue, drowsiness, muscle weakness, reduced alertness, confusion, headache, and ataxia. These typically diminish with continued use. Anterograde amnesia may occur at therapeutic doses.

Pregnancy & Lactation

Safety during pregnancy is not established; avoid use during lactation as bromazepam is excreted in breast milk.

Precautions & Warnings

Benzodiazepines like Nightus can lead to physical and psychological dependence, especially with prolonged use or in predisposed individuals. Gradual dosage reduction is recommended to minimize withdrawal symptoms. Caution advised when driving or using machinery. Not recommended for primary treatment of sleeplessness due to psychotic illness.

Therapeutic Class

Benzodiazepine sedatives.

Storage Conditions

Store in a dry place away from light and heat, and keep out of reach of children.