Migranil 1.5

Indications

Migranil is recommended for the preventive treatment of vascular headaches, including classical migraine, common migraine, and cluster headache. It is not effective for relieving ongoing migraine attacks.

Description

Migranil is a tricyclic compound that competitively blocks serotonin receptors. It possesses antihistamine, antibradykinin, and mild anticholinergic properties, along with appetite-stimulating effects.

Pharmacology

Pizotifen, the active ingredient in Migranil, inhibits serotonin and histamine actions in the periphery, reducing membrane permeability of cranial vessels and transudation of plasmakinin. It alters pain thresholds in migraines and blocks 5-HT receptors, thereby lessening cranial vasoconstriction and platelet function. It may also inhibit bradykinin actions and serotonin reuptake by blood platelets, leading to decreased distension of extracranial arteries.

Dosage & Administration

For adults, the usual dose is 1.5 mg daily, taken as a single dose at bedtime or in three divided doses. Dosage can be adjusted up to a maximum of 4.5 mg daily. For children over 2 years, up to 1.5 mg daily is recommended, usually divided, though up to 1 mg can be taken as a single dose at night.

Interaction

Migranil may enhance the central effects of sedatives, hypnotics, antihistamines (including some cold medications), and alcohol. It also counteracts the hypotensive effects of adrenergic neuron blockers.

Contraindications

Pizotifen is contraindicated in individuals with known hypersensitivity to any of its components.

Side Effects

Common side effects include increased appetite, weight gain, and drowsiness.

Pregnancy & Lactation

Limited information is available on the use of Pizotifen during pregnancy, but no adverse effects have been reported. It should only be used during pregnancy if the potential benefits outweigh the risks to the fetus. The safety of Pizotifen during lactation has not been established; thus, breastfeeding mothers should avoid its use.

Precautions & Warnings

Caution is advised in patients with urinary retention or renal impairment. Drowsiness may impair driving and machine operation. Migranil can potentiate the effects of alcohol.

Therapeutic Class

Migranil belongs to the therapeutic class of anti-histamine preparations and other drugs for migraine.

Storage Conditions

Store Migranil in a dry place away from light and heat, and keep it out of the reach of children.