Lomequin Eye/Ear Drops

Indications

Lomequin ophthalmic solution is designed to treat bacterial infections of the eye, including conjunctivitis, blepharitis, and blepharoconjunctivitis caused by Lomequin-sensitive bacteria. It is also effective against corneal ulcers induced by Staphylococcus aureus.

Pharmacology

Lomefloxacin, a difluorinated quinolone derivative, acts as a bacterial gyrase inhibitor, showcasing efficacy against both gram-positive and gram-negative bacteria. The systemic and topical ocular application of Lomefloxacin exhibits low acute toxicity. It disrupts essential bacterial DNA processes, including initiation, elongation, and termination phases of replication, transcription, DNA repair, recombination, transposition, and supercoiling. The primary target for quinolones is the A-subunit of bacterial gyrase (topoisomerase II). The formation of a stable complex between quinolone and the gyrase tetramer (A2B2) leads to impaired enzyme function, resulting in rapid bactericidal activity against susceptible strains.

Cross-resistance has been documented only with other quinolones, with no reported interactions with different antibiotic classes. Current clinical studies do not confirm efficacy against chlamydial infections.

Dosage

For Adults and Children (over 1 year): Instill 1 drop into the lower conjunctival sac 2-3 times daily. For initial treatment, more frequent applications may be necessary: apply 5 drops within 20 minutes or 1 drop every hour for 6-10 hours. Treatment duration typically ranges from 7 to 9 days.
Consult your healthcare provider for appropriate use.

Administration

Lomequin can be administered with or without food.
Consult your healthcare provider for appropriate use.

Interaction

To maintain optimal efficacy, avoid using ophthalmic preparations containing heavy metals (such as zinc) within 15 minutes before and after applying Lomequin. Concurrent use with bacteriostatic ophthalmic antibiotics is not recommended.

Contraindications

Do not use if you are hypersensitive to Lomequin, its excipients, or other quinolone antibiotics. Long-term antibiotic use may increase the risk of secondary fungal infections or the proliferation of resistant bacteria.

Side Effects

Transient burning sensations immediately following instillation have been reported in 4.7% of users. Although phototoxicity has not been observed with ophthalmic use, there is a possibility of photosensitization. Allergic reactions associated with systemic use, including asthma, dyspnea, urticaria, erythema, pruritus, and hypersensitivity, cannot be ruled out after topical application.

Pregnancy & Lactation

Animal studies indicate that Lomefloxacin crosses the placental barrier and is excreted in breast milk after systemic administration at a dose of 20 mg/kg. Due to a lack of clinical studies on the use of Lomefloxacin eye drops during pregnancy and lactation, this medication should only be utilized when the benefits outweigh the potential risks to the fetus or infant.

Precautions & Warnings

While isolated cases of phototoxicity have been documented following systemic use, no such effects have been noted with topical ophthalmic use. However, it is advisable to avoid excessive exposure to sunlight or UV radiation during treatment with Lomequin.

Overdose Effects

There is minimal risk of adverse effects from accidental oral ingestion, as a 5 ml bottle of Lomequin contains only 15 mg of the active ingredient, representing just 3.75% of the recommended oral daily dose for adults (400 mg).

Therapeutic Class

• 4-Quinolone preparations
• Ophthalmic antibacterial agents

Storage Conditions

Store at a temperature between 15-25°C.