Levoxin TS Eye Drop

Indications

Levoxin TS Eye Drops are indicated for treating bacterial conjunctivitis caused by susceptible strains of the following bacteria:

Aerobic Gram-Positive Bacteria:

• Corynebacterium species
• Staphylococcus aureus
• Staphylococcus epidermidis
• Streptococcus pneumoniae
• Streptococcus (Groups C/F)
• Streptococcus (Group G)
• Streptococcus viridans group

Aerobic Gram-Negative Bacteria:

• Acinetobacter iwoffi
• Haemophilus influenzae
• Serratia marcescens

In addition to conjunctivitis, Levoxin TS is effective against other ocular infections such as bacterial corneal ulcers, blepharitis, hordeolum, and perioperative conditions.

Pharmacology

Levofloxacin Eye Drops is a sterile topical ophthalmic solution classified as a third-generation fluoroquinolone antibiotic. This broad-spectrum, bactericidal agent targets a wide range of Gram-positive and Gram-negative ocular pathogens. Its mechanism of action involves inhibiting bacterial topoisomerase IV and DNA gyrase, enzymes crucial for DNA replication, transcription, repair, and recombination.

Dosage & Administration

0.5% Eye Drops: For Adults and Children Aged 1 Year and Older:

• Days 1 and 2: Administer 1-2 drops in the affected eye(s) every 2 hours while awake, not exceeding 8 times daily.
• Days 3 through 7: Administer 1-2 drops in the affected eye(s) every 4 hours while awake, up to 4 times daily.

1.5% Eye Drops: For Adults and Children Aged 6 Years and Older:

• Days 1 through 3: Administer 1-2 drops in the affected eye(s) every 30 minutes to 2 hours while awake, and approximately 4 to 6 hours after bedtime.
• Day 4 until treatment completion: Administer 1-2 drops in the affected eye(s) every 1 to 4 hours while awake.

Children Under 1 Year: Safety and effectiveness of Levofloxacin in children below 1 year of age have not been established.
Always follow the advice of your healthcare professional.

Interactions

While specific interaction studies for Levoxin TS Eye Drops have not been conducted, systemic administration of certain quinolones may elevate plasma levels of theophylline, alter caffeine metabolism, and enhance the effects of oral anticoagulants like warfarin and its derivatives.

Contraindications

Levoxin TS Eye Drops are contraindicated for individuals with a known hypersensitivity to levofloxacin, other quinolones, or any of the components in this formulation.

Side Effects

Side effects occur in approximately 1-3% of patients and may include:

• Transient blurred vision
• Fever
• Foreign body sensation
• Headache
• Ocular burning
• Ocular pain or discomfort
• Pharyngitis
• Photophobia

In less than 1% of patients, rare side effects such as allergic reactions, lid edema, ocular dryness, and ocular itching may occur.

Pregnancy & Lactation

Pregnancy Category C: Levofloxacin should be used during pregnancy only if the potential benefits outweigh the potential risks to the fetus. The presence of levofloxacin in human milk has not been established, so caution is advised when administering these eye drops to nursing mothers.

Precautions & Warnings

Prolonged use of Levoxin TS may lead to the overgrowth of non-susceptible organisms, including fungi. If a superinfection occurs, discontinue use and consider alternative therapies.

Therapeutic Class

• 4-Quinolone Preparations

Storage Conditions

Store Levoxin TS Eye Drops in a cool, dry place (15°-25°C), protected from light, and out of reach of children.