Lamitrin ER 100

Indications

Lamitrin ER is a prescription antiepileptic drug (AED) indicated for:

• Epilepsy: As an adjunctive therapy for patients aged 2 years and older, treating:
  • Partial-onset seizures
  • Primary generalized tonic-clonic seizures
  • Generalized seizures in Lennox-Gastaut syndrome
• Epilepsy: Monotherapy for patients aged 16 years and older.
• Bipolar disorder: For adults aged 18 years and older.

Always use Lamitrin ER under the guidance of a registered healthcare professional.

Description

Lamitrin ER is an effective treatment for epilepsy and bipolar disorder, belonging to the phenyltriazine class of antiepileptic drugs. It works by inhibiting voltage-sensitive sodium channels, which helps stabilize neuronal membranes and reduce the release of excitatory neurotransmitters like glutamate and aspartate, thereby controlling seizures and mood fluctuations.

Pharmacology

While the precise mechanism of action of Lamitrin ER is not fully understood, it is believed to work similarly to other antiepileptics, such as phenytoin and carbamazepine, by inhibiting voltage-sensitive sodium channels. Lamotrigin’s action also includes suppression of glutamate release, which contributes to its anticonvulsant effects. Additionally, it has been shown to interact with several receptors and may contribute to its effectiveness in managing some types of neuropathic pain.

Dosage & Administration

For Epilepsy (Patients Over 12 Years)

Weeks 1 & 2:

• Not taking Carbamazepine, Phenytoin, Phenobarbital, Primidone, or Valproate: 25 mg daily
• Taking Valproate: 25 mg every other day
• Taking Carbamazepine, Phenytoin, Phenobarbital, or Primidone (not Valproate): 50 mg daily

Weeks 3 & 4:

• Adjust doses based on concomitant medications. Refer to detailed dosage charts for adjustments.

Weeks 5 Onward (Maintenance Dose):

• Increase dosage gradually, based on the presence of other medications, to maintain seizure control.

For Epilepsy (Patients Aged 2 to 12 Years)

Weeks 1 & 2:

• Not taking Carbamazepine, Phenytoin, Phenobarbital, Primidone, or Valproate: 0.3 mg/kg/day
• Taking Valproate: 0.15 mg/kg/day
• Taking Carbamazepine, Phenytoin, Phenobarbital, or Primidone (not Valproate): 0.6 mg/kg/day

Weeks 3 & 4:

• Adjust doses according to weight and concurrent medications. Maximum recommended doses outlined in detailed regimen charts.

For Bipolar Disorder (Adults)

Weeks 1 & 2:

• Not taking Carbamazepine, Phenytoin, Phenobarbital, Primidone, or Valproate: 25 mg daily
• Taking Valproate: 25 mg every other day

Weeks 3 & 4:

• Adjust doses as required, based on concomitant treatments for optimal mood stabilization.

Interactions

Lamitrin ER may interact with several drugs, including:

• Valproate: Increases Lamitrin ER levels.
• Carbamazepine, Phenytoin, Phenobarbital, Rifampin: Decreases Lamitrin ER levels.
• Oral contraceptives (Estrogen-containing): Reduce Lamitrin ER effectiveness.
• Protease inhibitors: Can lower Lamitrin ER concentrations.

Side Effects

Common Side Effects:

• Adults: Dizziness, headache, blurred vision, nausea, rash, and somnolence.
• Children: Vomiting, diarrhea, abdominal pain, fever, and tremors.

Pregnancy & Lactation

Lamitrin ER is classified as Pregnancy Category C. It is excreted in breast milk, and its use during breastfeeding should be evaluated by a healthcare provider to weigh the potential risks to the infant.

Precautions & Warnings

• Discontinue treatment at the first signs of a rash.
• Monitor for signs of blood disorders, anemia, infection, or bleeding.
• Suicidal thoughts or behavior: Regular monitoring is advised.
• Aseptic meningitis is a rare, but serious condition associated with this drug.

Use in Special Populations

• Pediatric Use: Not recommended for children under 2 years for adjunctive treatment in epilepsy.
• Geriatric Use: Limited studies in patients aged 65+ years.

Overdose Effects

Symptoms of overdose may include ataxia, seizures, and a decreased level of consciousness. Immediate medical attention is required.

Therapeutic Class

Lamitrin ER belongs to the class of anti-epileptic drugs (AEDs), primarily used to manage epilepsy and bipolar disorder.

Storage Conditions

Store at temperatures below 25°C, in a dry place, and protect from light. Keep out of reach of children.