Veratin

Indications

Veratin tablet is indicated for the treatment of the following conditions:

• Strongyloidiasis: Intestinal strongyloidiasis caused by Strongyloides stercoralis
• Onchocerciasis: Onchocerciasis due to Onchocerca volvulus
• Filariasis
• Scabies
• Head Lice

Strongyloidiasis: Veratin is used for the treatment of intestinal strongyloidiasis, with a high cure rate following a single dose of 200 mcg/kg.

Onchocerciasis: Veratin is also effective against onchocerciasis, supported by randomized clinical studies in endemic regions of West Africa.

Pharmacology

Veratin contains Ivermectin, which binds selectively to glutamate-gated chloride ion channels in invertebrate nerve and muscle cells. This leads to an increase in chloride ion permeability, causing hyperpolarization of the cells and eventually killing the parasite.

Dosage & Administration

• For Treatment (COVIO Positive):
  • 2 Veratin tablets (6 mg) once daily for 5 days.
• For Prophylaxis:
  A single-dose regimen to be taken on Day 1 and repeated on Day 7.
  Dosage depends on body weight, ranging from 1 to 3 tablets (3 mg or 6 mg per tablet).
• Strongyloidiasis:
  A single oral dose of Veratin, approximately 200 mcg/kg of body weight, is recommended.
  Dosage Guidelines for Strongyloidiasis:
  • 15-24 kg: 3 mg/kg
  • 25-35 kg: 6 mg/kg
  • 36-50 kg: 9 mg/kg
  • 51-65 kg: 12 mg/kg

  • 80 kg: 200 mcg/kg

• Onchocerciasis:
  A single dose of approximately 150 mcg/kg, with intervals of 12 months or as directed.
  Dosage Guidelines for Onchocerciasis:
  • 15-25 kg: 3 mg/kg
  • 26-44 kg: 6 mg/kg
  • 45-64 kg: 9 mg/kg

  • 85 kg: 150 mcg/kg

Interaction

• Rare interactions with anticoagulants like Warfarin, potentially increasing INR (International Normalized Ratio).

Contraindications

• Not recommended for patients with known hypersensitivity to any component of this drug.

Side Effects

• Strongyloidiasis: Mild side effects include fatigue, abdominal pain, nausea, vomiting, dizziness, and mild skin reactions.
• Onchocerciasis: Possible reactions include lymph node enlargement, rash, fever, and eye-related symptoms, though most symptoms resolve without treatment.

Pregnancy & Lactation

• Pregnancy: Category C. Safety has not been established during pregnancy.
• Lactation: Ivermectin is excreted in breast milk; use with caution during breastfeeding.

Precautions & Warnings

• Caution is advised in patients with a history of Mazzotti reactions or those with Loa loa co-infection.
• Use in pediatric patients under 15 kg and elderly patients should be considered on a case-by-case basis.

Storage

Store below 30°C in a dry place, away from light. Keep out of reach of children.