Clovate N Cream

Indications for Clovate N Cream

Clovate N is a potent topical treatment indicated for a range of inflammatory skin conditions, including:

• Eczema: Particularly for stubborn cases not responding to milder steroids.
• Neurodermatoses: For inflammatory skin disorders like lichen simplex.
• Psoriasis: Specifically in cases where secondary infections (bacterial or fungal) are suspected or present.
• Other Resistant Conditions: For other inflammatory dermatoses unresponsive to less potent steroids.

Always follow a healthcare professional’s advice for use.

Pharmacology of Clovate N

Clovate N combines three powerful active ingredients for optimal skin healing:

• Clobetasol Propionate: A highly potent corticosteroid that helps to reduce inflammation, swelling, and redness.
• Neomycin Sulphate: An antibiotic that fights bacterial infections by inhibiting protein synthesis in bacterial cells.
• Nystatin: A topical antifungal that combats fungal infections by altering cell membrane permeability.

Together, these components work synergistically to treat severe dermatological conditions effectively.

Dosage & Administration

Clovate N should be used as follows:

• Adults: Apply a thin layer of cream or ointment to affected areas 1-2 times daily. Do not exceed 7 days of continuous use without medical supervision.
• Elderly: Suitable for elderly individuals, though caution is advised if renal function is impaired.
• Children (over 2 years): Apply as per adult dosage, but avoid use in infants under 2 years due to potential increased absorption.

Consult a doctor before use to ensure proper treatment duration and method.

Drug Interactions

• Neomycin can enhance the effects of neuromuscular blocking agents, but significant systemic exposure is unlikely when used as directed.
• No significant interactions have been reported with Clobetasol Propionate or Nystatin.

Contraindications

Clovate N should not be used in individuals with:

• Rosacea, Acne vulgaris, or Perioral dermatitis
• Primary cutaneous viral infections (e.g., Herpes simplex, chickenpox)
• Known hypersensitivity to any component of the formulation.

Side Effects

• Prolonged use of Clovate N may lead to systemic absorption, causing symptoms of hypercortisolism such as weight gain, thinning skin, and high blood sugar.
• Skin atrophy (thinning of skin) and stretch marks may develop, especially with occlusive dressings or in sensitive areas.
• Hypertrichosis (excessive hair growth) and pigmentation changes have also been reported.

Pregnancy & Lactation

There is limited information on the safety of Neomycin and Clobetasol Propionate during pregnancy and lactation. It’s advised to avoid using Clovate N during pregnancy unless the benefit outweighs the potential risks. It’s also unknown if Clobetasol Propionate passes into breast milk, so consult a healthcare provider before use in nursing mothers.

Precautions & Warnings

• Long-term use of topical corticosteroids in infants and children can lead to adrenal suppression.
• Avoid applying to the eyelids, as this can lead to eye conditions like glaucoma. If it enters the eye, rinse immediately with plenty of water.
• If symptoms worsen or do not improve, stop use and seek medical advice.

Overdose Effects

While acute overdosage is unlikely, chronic misuse can lead to hypercortisolism. In such cases, reduce usage gradually and consult a healthcare professional.

Storage Instructions

• Store at temperatures below 25°C, away from light and moisture.
• Do not freeze.
• Keep out of reach of children.