Clovate Cream

Indications

Clovate is indicated for the treatment of various skin conditions in both adults and children over 1 year of age. It is particularly effective in treating:

• Psoriasis (excluding widespread plaque psoriasis)
• Recalcitrant dermatoses
• Lichen planus
• Discoid lupus erythematosus
• Other resistant skin conditions that do not respond to milder steroid treatments.

Always follow the advice of a registered healthcare provider before use.

Composition

• Clobetasol Propionate Cream/Ointment: Each gram contains 0.5 mg of Clobetasol Propionate BP (0.05% w/w).
• Clobetasol Propionate Scalp Application/Lotion: Each gram contains 0.5 mg of Clobetasol Propionate BP (0.05% w/w).
• Clobetasol Propionate Shampoo: Each gram contains 0.5 mg of Clobetasol Propionate BP (0.05% w/w).
• Clobetasol Propionate Spray: Each gram contains 0.5 mg of Clobetasol Propionate BP (0.05% w/w).

Pharmacology

Clobetasol Propionate is a potent topical corticosteroid with powerful anti-inflammatory, antipruritic, and vasoconstrictive effects. It works by:

• Reducing the activity of mast cells and eosinophils.
• Suppressing the production of pro-inflammatory cytokines.
• Inhibiting arachidonic acid metabolism, which reduces the synthesis of key inflammatory mediators (prostaglandins and leukotrienes).

It also has immunosuppressive properties, reducing immune system function by affecting lymphocytes and immunoglobulins.

Dosage & Administration

• Cream/Ointment: Apply a thin layer to the affected areas twice daily. The maximum weekly dose should not exceed 50 gm/week. For children, limit treatment to 5 days.
• Spray: Apply to the affected scalp areas 1-2 times daily. The total dosage should not exceed 50 ml per week.
• Shampoo: Apply to a dry scalp, leave for 15 minutes before rinsing. Do not exceed 50 g per week, and limit use to 4 weeks.

Always follow the prescribed guidelines from your healthcare provider.

Contraindications

Clovate should not be used in:

• Patients with rosacea, acne vulgaris, or perioral dermatitis.
• Active skin infections (bacterial, viral, fungal).
• Children under one year.

It should also not be used in infected skin conditions, including fungal or bacterial infections like impetigo or candidiasis.

Side Effects

Potential side effects include:

• Skin thinning or striae with long-term use.
• Hypercorticism from excessive use, especially on large areas.
• Possible exacerbation of psoriasis, including pustular outbreaks.
• Rare cases of pigmentation changes or hypertrichosis.

Discontinue use immediately if hypersensitivity reactions occur.

Pregnancy & Lactation

• Pregnancy: Use Clobetasol Propionate during pregnancy only if absolutely necessary, as it may cause fetal development issues in animal studies.
• Lactation: It is unknown if the drug passes into breast milk, so use with caution during breastfeeding.

Precautions & Warnings

• Avoid prolonged use on the face and in children, as it may cause adrenal suppression.
• Use caution when applying near the eyes, as it may lead to glaucoma or cataracts.
• Monitor patients with psoriasis carefully, as topical steroids may worsen the condition.
• If signs of infection occur, discontinue corticosteroid therapy and begin anti-microbial treatment.

Overdose Effects

Overuse may lead to symptoms of hypercortisolism. Discontinue treatment immediately if overdose symptoms appear.

Therapeutic Class

• Class: Other Topical Corticosteroids

Storage Conditions

Store Clovate below 30°C, away from moisture and direct sunlight. Do not freeze and keep out of reach of children.