Bisocor Plus 2.5/6.25
60.20৳ Strip
- Experience effective hypertension management with Bisocor Plus, a powerful combination of Bisoprolol Fumarate and Hydrochlorothiazide.
- Benefit from the β1-selective adrenoceptor blocking action of Bisoprolol coupled with Hydrochlorothiazide’s diuretic properties for enhanced antihypertensive effects.
- Our carefully titrated doses ensure optimal blood pressure control while minimizing the risk of hypokalemia.
- Trust Bisocor Plus to provide a comprehensive solution for hypertension treatment with minimal side effects.
Brand
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Square Pharmaceuticals PLC |
|---|---|
Generics
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Bisoprolol Fumarate + Hydrochlorothiazide |
Indications
Bisoprolol combined with Hydrochlorothiazide is prescribed for managing hypertension.
Pharmacological Details
Both Bisoprolol Fumarate and Hydrochlorothiazide are commonly utilized, either alone or in tandem, for hypertension treatment. The combined effect enhances their antihypertensive properties; notably, a dosage of Hydrochlorothiazide 6.25 mg considerably boosts the antihypertensive impact of Bisoprolol Fumarate. Additionally, the occurrence of hypokalemia is markedly lower with the Bisoprolol Fumarate and Hydrochlorothiazide 6.25 mg blend compared to Hydrochlorothiazide 25 mg. Bisoprolol Fumarate acts as a β1-selective adrenoceptor blocking agent, while Hydrochlorothiazide functions as a benzothiadiazine diuretic, affecting renal electrolyte reabsorption mechanisms.
Dosage & Administration
Bisoprolol is effective in daily doses ranging from 2.5 to 40 mg for hypertension, while Hydrochlorothiazide is efficacious in doses of 12.5 to 50 mg. Clinical trials on Bisoprolol/Hydrochlorothiazide combination therapy revealed escalating antihypertensive effects with increasing doses of either component. The recommended initial therapy involves a once-daily intake of one 2.5/6.25 mg tablet, with subsequent titration at 14-day intervals up to a maximum daily dose of 20/12.5 mg, as per clinical necessity.
Interactions
The concurrent use of Bisocor Plus with other antihypertensive agents may amplify its effects. However, combining it with other beta-blocking agents is not advisable. Caution is advised when using Bisocor Plus alongside certain medications like clonidine, myocardial depressants, or AV conduction inhibitors, as it may lead to adverse reactions or exacerbate existing conditions.
Contraindications
Bisocor Plus is contraindicated in patients with specific conditions such as cardiogenic shock, overt cardiac failure, second or third degree AV block, marked sinus bradycardia, anuria, or hypersensitivity to its components or other sulfonamide-derived drugs.
Side Effects
Typically well-tolerated, Bisocor Plus may cause mild and transient side effects like fatigue, dizziness, headache, bradycardia, or gastrointestinal disturbances. Monitoring and medical advice are recommended if any adverse effects persist or worsen.
Pregnancy & Lactation
Usage during pregnancy (Category C) or lactation should be carefully considered, weighing the potential benefits against the risks to the fetus or nursing infant.
Precautions & Warnings
Patients should be monitored for signs of fluid and electrolyte imbalance, especially those at risk of hyperuricemia or acute gout. Gradual withdrawal of Bisocor Plus is recommended if discontinuation is planned.
Overdose Effects
Overdose symptoms may include bradycardia, hypotension, lethargy, and electrolyte imbalance. Management involves supportive measures and monitoring for complications.
Therapeutic Class
Bisocor Plus falls under the category of combined antihypertensive preparations.
Storage Instructions
Store below 30°C, away from light and moisture, and out of reach of children.
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