Xenole 500

Indications

Naproxen & Esomeprazole is prescribed for alleviating symptoms of:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Reducing the risk of developing gastric ulcers in patients prone to NSAID-associated gastric ulcers.

Pharmacology

This medication comprises an immediate-release layer of Esomeprazole Magnesium and an enteric-coated Naproxen core. Esomeprazole is released in the stomach before Naproxen dissolves in the small intestine.

Naproxen, an NSAID, possesses analgesic and antipyretic properties by inhibiting prostaglandin synthesis. Esomeprazole, a proton pump inhibitor, reduces gastric acid secretion by specifically inhibiting the H+/K+ -ATPase in the gastric parietal cell.

Dosage

Consider the benefits and risks before using this tablet or other treatments. Administer the lowest effective dose for the shortest duration aligned with individual patient treatment goals. Dosage recommendations for various conditions are provided based on adult and adolescent patient criteria.

Administration

Take the tablet at least 30 minutes before meals without splitting, chewing, crushing, or dissolving it.

Interactions

This tablet may interact with certain medications and foods, affecting their absorption or effectiveness. Caution is advised with concurrent use of NSAIDs, warfarin, and drugs affected by gastric pH.

Contraindications

Avoid this tablet if there’s a known hypersensitivity to any component or substituted benzimidazoles, history of allergic-type reactions to aspirin or other NSAIDs, or during peri-operative period in CABG surgery.

Side Effects

Immediate release esomeprazole in the tablet helps reduce gastrointestinal side effects from Naproxen. Common adverse events include gastrointestinal symptoms. Consideration of potential cardiovascular and renal effects is also warranted.

Pregnancy & Lactation

Avoid during the third trimester of pregnancy and breastfeeding. Use in women attempting to conceive or during the first and second trimester should weigh potential benefits against risks.

Precautions & Warnings

Exercise caution in specific populations such as elderly, patients with renal impairment, and those with hepatic insufficiency. Monitor for adverse effects and adjust dosage as necessary.

Overdose Effects

Management involves symptomatic and supportive care. Specific antidotes are not available. Hemodialysis is ineffective due to high protein binding of Naproxen.

Therapeutic Class

This medication falls under the category of drugs for osteoarthritis, rheumatoid arthritis, and NSAIDs.

Storage Conditions

Store below 30°C, protected from light and moisture, and out of reach of children.