Tycil PFS

Indications

Tycil is prescribed for the treatment of infections caused by susceptible β-lactamase negative strains of microorganisms. It is effective for:

• Ear, Nose, and Throat Infections: Such as otitis media, sinusitis, tonsillitis, pharyngitis, and laryngitis.
• Lower Respiratory Tract Infections: Including pneumonia, acute and chronic bronchitis, lung abscess, empyema, and bronchiectasis.
• Skin and Soft Tissue Infections: Such as cellulitis, carbuncles, furunculosis, infected wounds, and abscesses.
• Genitourinary Tract Infections: Including pyelonephritis, cystitis, and urethritis.
• Venereal Diseases: Such as acute uncomplicated gonorrhea.
• Dental Abscess: Used for short-term treatment.
• H. pylori Infection and Duodenal Ulcer Disease: Administered in combination with Clarithromycin and Lansoprazole as triple therapy to treat H. pylori infections and reduce the risk of duodenal ulcer recurrence.

Pharmacology

Amoxicillin, a broad-spectrum penicillin, is effective against a variety of Gram-positive and Gram-negative bacteria. It works by inhibiting cell wall biosynthesis. Amoxicillin is stable in gastric acid and is rapidly absorbed after oral administration, reaching peak plasma concentrations within 1 to 2 hours. It is widely distributed in body tissues and fluids.

Dosage

• Adults: 250 mg three times daily, increasing to 500 mg three times daily for severe infections.
• Children (up to 10 years): 125 mg three times daily, increasing to 250 mg three times daily for severe infections.

  Specific dosages:

  • Severe or Recurrent Purulent Respiratory Infection: 3 g every 12 hours.
  • Otitis Media: 1 g three times daily for adults, and 40 mg/kg daily in 3 divided doses for children (max. 3 g daily).
  • Pneumonia: 500-1000 mg three times daily.
  • Dental Abscess: 3 g, repeated after 10-12 hours.
  • Urinary Tract Infections: 3 g, repeated after 10-12 hours.
  • Gonorrhea: A single dose of 2-3 g with 1 g Probenecid (not recommended for children under 2 years).

Always consult a healthcare provider before use.

Administration

The reconstituted suspension can be mixed with milk, fruit juice, or water and should be consumed immediately.

Interaction

Concurrent use of Tycil with Probenecid may lead to increased and prolonged blood levels of Tycil. It may also affect gut flora, reducing the efficacy of combined oral contraceptives.

Contraindications

Amoxicillin is contraindicated in individuals with a known hypersensitivity to penicillin.

Side Effects

Side effects are generally mild and may include diarrhea, indigestion, and occasionally a rash. Pseudomembranous colitis has been reported rarely.

Pregnancy & Lactation

Amoxicillin falls under US FDA pregnancy category B. Due to a lack of adequate studies in pregnant women, it should only be used if necessary. Amoxicillin is excreted in human milk; caution is advised when administering to breastfeeding mothers.

Precautions & Warnings

Monitor for potential superinfections with mycotic or bacterial pathogens. If superinfections occur, discontinue Tycil and initiate appropriate treatment.

Therapeutic Class

Broad-spectrum penicillins

Reconstitution

Amoxicillin 500 mg Injection:

• Intramuscular: Add 2.5 ml of water for injection to the Amoxicillin 500 mg vial.
• Intravenous: Dissolve Amoxicillin 500 mg in 10 ml of water for injection.

Storage Conditions

Store in a dry place away from light and heat. Keep out of reach of children.