Indications
Trumega serves as a supplementary treatment to lower extremely high triglyceride levels (>500mg/dl) in adult patients and as an additional therapy for secondary prevention in those who have experienced a heart attack within the last 3 months. It also aids in reducing joint inflammation linked with mild arthritis, managing mood disorders & impulse control, and addressing age-related macular degeneration.
Composition
Each Soft Gelatin Capsule contains Omega-3-Acid Ethyl Esters BP 1000 mg, comprising:
- Eicosapentaenoic Acid BP 80 mg
- Docosahexaenoic Acid BP 120 mg
Pharmacology
Omega-3-acid ethyl esters help lower triglyceride production by the liver through mechanisms that include inhibiting triglyceride synthesis and enhancing fatty acid metabolism. Additionally, they promote triglyceride clearance and reduce very low-density lipoprotein cholesterol production.
Dosage & Administration
- For hypertriglyceridemia: A single dose of 4 capsules (4 gm) or 2 capsules (2 gm) twice daily.
- For post-myocardial infarction patients: 1 capsule (1 gm) daily with food.
- For joint inflammation related to mild arthritis: 2.7 gm daily.
- For mood disorders & impulse control and age-related macular degeneration: 1 capsule (1 gm) per day, or as directed by a registered physician.
Follow the advice of a healthcare professional when using medication.
Interaction
Trumega-acid ethyl esters can be administered alongside warfarin without causing hemorrhagic complications. However, prothrombin time should be monitored during concurrent use or discontinuation of treatment.
Contraindications
Avoid in patients with hypersensitivity to any component of this medication.
Side Effects
Adverse reactions may include gastrointestinal issues, immune system disorders, metabolic disorders, nervous system disorders, and vascular disorders.
Pregnancy & Lactation
Use during pregnancy should be carefully considered based on the potential benefit versus risk. Caution is advised during lactation.
Precautions & Warnings
Patients on anticoagulant therapy should be monitored due to a moderate increase in bleeding time with higher dosages. Use with caution in patients at high risk of hemorrhage.
Therapeutic Class
Belongs to the category of other lipid-regulating drugs.
Storage Conditions
Store below 25°C in a dry and cool place.
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