Indications
This inhalation capsule is indicated for:
- Long-term maintenance treatment of chronic obstructive pulmonary disease (COPD) in patients.
- Long-term maintenance treatment of asthma in patients aged 18 years and older.
Please note it is not intended for acute bronchospasm relief.
Composition
Each dry powder inhaler capsule contains:
- Vilanterol Trifenatate 25 mcg (as Vilanterol Trifenatate INN)
- Fluticasone Furoate INN 100 mcg or 200 mcg
- Umeclidinium 62.5 mcg (as Umeclidinium Bromide INN)
Pharmacology
This capsule combines fluticasone furoate (an ICS), umeclidinium (an anticholinergic), and vilanterol (a LABA) for oral inhalation delivery. It works by stimulating intracellular adenyl cyclase, leading to bronchial smooth muscle relaxation and inhibition of hypersensitivity mediators.
Dosage & Administration
For adults aged 18 and older, use one inhalation capsule once daily, at the same time each day. It’s essential not to swallow the capsule and to rinse the mouth after inhalation.
Interaction
Caution is advised when using with certain medications like strong cytochrome P450 3A4 inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, beta-blockers, diuretics, and other anticholinergics.
Contraindications
Avoid in primary treatment of status asthmaticus or acute COPD or asthma episodes, and in patients with severe hypersensitivity to milk proteins or any ingredients.
Side Effects
Common adverse reactions may include upper respiratory tract infections, oral candidiasis, headache, and urinary tract infections.
Precautions & Warnings
Various precautions apply, including the increased risk of serious asthma-related events with LABA monotherapy, avoidance in acutely deteriorating COPD or asthma, and caution in patients with cardiovascular disorders, convulsive disorders, and others.
Overdose Effects
There’s no available data on overdose with this inhalation capsule.
Therapeutic Class
This combination falls under the category of combined bronchodilators for COPD and asthma management.
Storage Conditions
Store in a cool, dry place, away from direct sunlight or heat, and keep out of reach of children.
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