Tenaxit

Indications

The Flupentixol and Melitracen tablet is prescribed for the treatment of various conditions, including:

• Anxiety and Generalized Anxiety Disorder (GAD)
• Depression (including psychogenic and depressive neuroses)
• Apathy and Masked Depression
• Psychosomatic disorders associated with anxiety and apathy
• Menopausal depression
• Dysphoria and depression linked to alcohol and drug addiction

Consult a registered healthcare provider before use.

Pharmacology

This medication combines two well-established compounds: Flupentixol, a neuroleptic with anxiolytic and antidepressant effects at low doses, and Melitracen, a thymoleptic with mood-enhancing properties. Together, these ingredients provide a balanced formula that delivers antidepressant, anxiolytic, and activating effects.

• Flupentixol reaches maximum serum concentration within approximately 4 hours after oral intake, with a half-life of about 35 hours.
• Melitracen also peaks within 4 hours of oral administration, with a half-life of around 19 hours.

The combination of Flupentixol and Melitracen does not affect the pharmacokinetics of each individual compound.

Dosage & Administration

For Adults:

• Typically, 2 tablets daily, taken in the morning and at noon. In more severe cases, the morning dose may be increased to 2 tablets.

For Elderly Patients:

• Start with 1 tablet in the morning.

Maintenance Dose:

• Generally, 1 tablet in the morning. For patients experiencing insomnia or severe restlessness, additional sedative treatment may be required during the acute phase.

Always follow the advice of a registered healthcare provider.

Drug Interactions

This medication may increase sensitivity to alcohol, barbiturates, and other CNS depressants. Co-administration with MAO inhibitors can lead to hypertensive crises. Additionally, the combined use of neuroleptics and thymoleptics may reduce the antihypertensive effects of guanethidine and similar drugs, while enhancing the effects of adrenaline and noradrenaline.

Contraindications

Do not use this tablet in the following conditions:

• Immediate recovery phase following a myocardial infarction
• Bundle-branch conduction defects
• Untreated narrow-angle glaucoma
• Acute intoxication with alcohol, barbiturates, or opioids
• Patients who have used MAO inhibitors within the last two weeks
• Not recommended for excitable or hyperactive individuals due to the activating effects of the medication

Side Effects

When taken at the recommended doses, side effects are rare but may include transient restlessness and insomnia.

Pregnancy & Lactation

This medication is not recommended during pregnancy or lactation. Always consult a healthcare provider for personalized advice.

Precautions & Warnings

If the patient has previously been treated with sedative tranquilizers, these should be tapered off gradually.

Overdose Effects

In the event of an overdose, symptoms may predominantly reflect melitracen toxicity, particularly anticholinergic effects, with rarer extrapyramidal symptoms due to Flupentixol.
Treatment includes supportive care, gastric lavage, and activated charcoal. Respiratory and cardiovascular support should be provided as needed. Epinephrine (adrenaline) should not be used in overdose situations. Convulsions can be managed with diazepam, while extrapyramidal symptoms can be treated with biperiden.

Therapeutic Class

This medication is classified as a combined anxiolytic and antidepressant.

Storage Conditions

Store in a dry place at a temperature not exceeding 30°C. Protect from light and keep out of the reach of children.