Seroprex 100

Indications

Seroprex serves as a therapeutic solution for both acute and chronic psychoses, encompassing conditions like schizophrenia and Bipolar Disorder. Its applications include treating manic episodes meeting DSM-IV criteria for bipolar disorder, managing depressive episodes associated with bipolar disorder, and maintaining bipolar I disorder, when combined with a mood stabilizer, to prevent the recurrence of manic, depressive, or mixed episodes.

Pharmacology

Quetiapine Fumarate, an atypical psychotropic agent, falls into the dibenzothiazepine derivatives chemical class. Its mechanism of action involves antagonizing multiple neurotransmitter receptors in the brain, including serotonin 5HT1A and 5HT2, dopamine D1 and D2, histamine H1, and adrenergic α1 and α2 receptors. While its exact mechanism remains unclear, Quetiapine’s efficacy in schizophrenia is proposed to stem from its combination of dopamine D2 and serotonin 5HT2 antagonism. Notably, its effects on histamine H1 receptors may contribute to somnolence, and its impact on adrenergic α receptors may explain orthostatic hypotension.

Dosage & Administration

For conditions like acute and chronic psychoses, including schizophrenia, the recommended dosage of Quetiapine involves twice-daily administration, with or without food. The initial dosage starts at 50 mg on Day 1, escalating to 300 mg on Day 4, and then adjusting within the range of 300-450 mg/day based on individual patient response and tolerability.

In the case of manic episodes associated with bipolar disorder, Quetiapine should be taken twice daily, with or without food, beginning with 100 mg on Day 1 and increasing to 400 mg on Day 4. Dosage adjustments can continue up to 800 mg/day, depending on clinical response and individual patient tolerance.

For depressive episodes linked with bipolar disorder, Quetiapine is typically administered once daily at bedtime, with or without food. The usual dose is 300 mg/day, starting at 50 mg on Day 1 and reaching 300 mg on Day 4, with potential titration to 600 mg by Day 8 if needed.

Interaction

Caution is advised when using Seroprex alongside medications known to induce electrolyte imbalance or QT interval prolongation. Co-administration with certain drugs such as thioridazine, carbamazepine, or phenytoin may impact Seroprex clearance.

Contraindications

Quetiapine is contraindicated in individuals with hypersensitivity to the drug.

Side Effects

Commonly reported adverse reactions with Seroprex include somnolence, dizziness, dry mouth, withdrawal symptoms, changes in lipid levels, weight gain, decreased hemoglobin, and extrapyramidal symptoms.

Pregnancy & Lactation

The safety and efficacy of Quetiapine during pregnancy have not been established. Its use during pregnancy should be carefully weighed against potential risks. Breastfeeding women are advised to avoid Quetiapine due to uncertain excretion into breast milk.

Precautions & Warnings

Seroprex should be used cautiously in patients with cardiovascular or cerebrovascular diseases, considering its potential to induce orthostatic hypotension. Careful monitoring is recommended for patients with a history of seizures or those prone to tardive dyskinesia and extrapyramidal symptoms.

Use in Special Populations

Elderly patients should use Seroprex with caution, considering age-related differences in drug metabolism and clearance. Seroprex is not indicated for use in children and adolescents under 18 years of age.

Overdose Effects

Survival has been reported in cases of acute Seroprex overdose. There’s no specific antidote, and supportive care is recommended, including monitoring and management of cardiovascular function.

Therapeutic Class

Seroprex falls within the category of atypical neuroleptic drugs.

Storage Conditions

Store Seroprex in a cool, dry place away from children, and avoid use beyond the expiry date.