Rutix 400

Indications

Rutix tablets serve as an effective remedy for mild to moderate infections in adults caused by susceptible strains. These encompass various conditions such as:

• Lower Respiratory Tract Infections: Including acute bacterial exacerbation of chronic bronchitis, lung abscess, and pneumonia.
• Gastrointestinal Tract Infections: Targeting enteric fever and shigellosis.
• Multi-drug-resistant Tuberculosis.
• Skin and Skin Structure Infections: Treating uncomplicated cases.
• Sexually Transmitted Diseases: Addressing acute, uncomplicated urethral and cervical gonorrhoea, as well as nongonococcal urethritis and cervicitis, among others.
• Urinary Tract Infections: Both uncomplicated and complicated cases.

For ophthalmic and otic use, Rutix Eye & Ear Drops are recommended for:

• Eye Infections: Including conjunctivitis, keratitis, corneal ulcer, and pre-operative prophylaxis in ocular surgery.
• Ear Infections: Treating external and certain middle ear infections.

Pharmacology

Rutix contains ofloxacin, a synthetic antibacterial agent effective against a wide spectrum of Gram-negative and Gram-positive organisms. By inhibiting DNA gyrase, an essential enzyme in bacterial DNA replication, transcription, and repair, ofloxacin demonstrates bactericidal activity. Upon oral administration, it is rapidly absorbed, with nearly 100% bioavailability in tablet form. With a distribution into body tissues and fluids, its half-life ranges from 4.6 to 6.9 hours. The majority of the oral dose is excreted in urine within 48 hours.

Dosage & Administration

Dosage recommendations vary based on the type and severity of the infection. For adults, the range is typically 200 mg to 800 mg daily, with larger doses administered in divided doses. Specific dosing instructions are provided for different indications, including enteric fever, shigellosis, tuberculosis, and various infections of the respiratory, urinary, and reproductive systems. Special considerations are given for patients with impaired liver function, although Rutix is generally not recommended for children.

For Rutix Eye & Ear Drops, specific instructions are provided for instillation in the affected eye(s) and ear(s), with duration of treatment limited to avoid overgrowth of non-susceptible organisms and secondary infections.

Interaction

Certain antacids and minerals may interfere with the absorption of Rutix, necessitating caution when co-administering these substances.

Contraindications

Ofloxacin should be avoided in patients with known hypersensitivity to fluoroquinolone antibacterials, a history of epilepsy, or a lowered seizure threshold. It is generally contraindicated in children, pregnant or breastfeeding women.

Side Effects

While generally well-tolerated, Rutix tablets may cause gastrointestinal and central nervous system reactions, such as nausea, rash, headache, and dizziness. Transient ocular irritation and mild discomfort in the ear have been reported with Rutix Eye & Ear Drops.

Pregnancy & Lactation

The safety of ofloxacin during pregnancy and lactation has not been established; caution is advised.

Precautions & Warnings

Patients using Rutix should minimize exposure to strong sunlight and UV rays. Prolonged use of eye and ear drops may lead to overgrowth of non-susceptible organisms and secondary infections, warranting caution.

Therapeutic Class

Rutix belongs to the class of 4-Quinolone preparations and Aural Anti-bacterial preparations.

Storage Conditions

Store Rutix between 15-30°C, protecting from light.