Rosuva 5

Conditions for Use

Rosuva serves as a treatment for various conditions, including:

• Heterozygous Hypercholesterolemia (both familial and non-familial)
• Homozygous Hypercholesterolemia (familial)
• Mixed Dyslipidemia (Fredrickson Type IIa and IIb)
• Primary prevention of cardiovascular disease

Pharmacological Action

Rosuvastatin acts as a selective and competitive inhibitor of HMG-CoA reductase. This enzyme is pivotal in converting 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor of cholesterol. Rosuvastatin’s lipid-modifying effects are twofold: it enhances the number of hepatic LDL receptors, facilitating the uptake and catabolism of LDL, and it inhibits hepatic synthesis of VLDL, reducing the overall number of VLDL and LDL particles.

Dosage Information

The recommended dosage range for Rosuva is 5-40 mg once daily. The 40 mg dose is advised only for patients who do not reach their LDL-C goal with 20 mg.

For patients with HoFH, the starting dose is 20 mg/day. In pediatric patients with HeFH, the recommended dosage is 5-10 mg/day for those aged 8 to less than 10 years, and 5-20 mg/day for patients aged 10 to 17 years. Pediatric patients with HoFH should take 20 mg/day if aged 7 to 17 years.

Administration

Rosuvastatin can be taken with or without food at any time of the day, as advised by a healthcare professional.

Interactions

Notable drug interactions involving Rosuva include:

• Cyclosporine: Combination increases Rosuva exposure, limiting the Rosuva dose to 5 mg once daily.
• Gemfibrozil: Combination should be avoided. If used together, limit the Rosuva dose to 10 mg once daily.
• Lopinavir/Ritonavir or atazanavir/ritonavir: Combination increases Rosuva exposure, requiring the Rosuva dose to be limited to 10 mg once daily.
• Coumarin anticoagulants: Combination prolongs international normalized ratio (INR). Stable INR should be achieved before starting Rosuva, with frequent monitoring thereafter.

Contraindications

Rosuvastatin is contraindicated in individuals with:

• Known hypersensitivity to product components
• Liver disease, including unexplained persistent elevations in hepatic transaminase levels
• Pregnant or breastfeeding women

Side Effects

Rosuva is generally well-tolerated. Common adverse events associated with Rosuva include headache, myalgia, constipation, asthenia, abdominal pain, and nausea.

Pregnancy & Lactation

The safety of Rosuvastatin in pregnant women has not been established. It is uncertain whether Rosuvastatin is excreted in human milk.

Precautions & Warnings

Special precautions are necessary for:

• Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks are heightened with a 40 mg dose, advanced age (>65 years), hypothyroidism, renal impairment, and concurrent use of certain medications.
• Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic transaminases can occur, necessitating regular monitoring.

Use in Special Populations

The safety and effectiveness of Rosuvastatin in pediatric patients have not been established.

Storage Conditions

Store Rosuvastatin below 30°C, shielded from light and moisture, and out of reach of children.

Chemical Structure

• Molecular Formula: C22H28FN3O6S
• Chemical Structure: View the chemical structure of Rosuvastatin Calcium.

FAQs

Find answers to common questions about Rosuva:

• What is Rosuva 5 mg Tablet?
• What are the uses of Rosuva 5 mg Tablet?
• What are the side effects of Rosuva 5 mg Tablet?
• For how long should I take Rosuva 5 mg Tablet?
• Does Rosuva 5 mg Tablet cause weight gain?
• Does Rosuva 5 mg Tablet make you tired?
• Should Rosuva 5 mg Tablet be taken at night?
• What foods should be avoided when taking Rosuva 5 mg Tablet?
• How do I know whether Rosuva 5 mg Tablet is beneficial for me or not?
• Can Rosuva 5 mg Tablet cause memory loss?
• Is it true that Rosuva 5 mg Tablet can cause diabetes?
• Can I take alcohol with Rosuva 5 mg Tablet?
• Can Rosuva 5 mg Tablet cause muscle problems or muscle injury?

Quick Tips

• Rosuva 5 mg Tablet treats high cholesterol by lowering “bad” cholesterol (LDL) and triglycerides (fats). It should be complemented with regular exercise and a low-fat diet.
• In general, Rosuva 5 mg Tablet is safe. It may cause diarrhea, gas, or an upset stomach. If these occur, take it with food.
• Inform your doctor if you experience fatigue, muscle weakness, or muscle pain.
• Your doctor may check your liver function before and during treatment.
• Inform your doctor of any kidney disease, liver disease, or diabetes before starting treatment.
• Do not take Rosuva 5 mg Tablet if you are pregnant, planning pregnancy, or breastfeeding.