Rosuva 10

Medical Indications

Rosuvastatin serves as an effective treatment for various conditions, including:

• Heterozygous and Homozygous Hypercholesterolemia (Familial and Non-familial)
• Mixed Dyslipidemia (Fredrickson Type IIa and IIb)
• Primary prevention of cardiovascular disease

Pharmacological Action

Rosuvastatin acts as a selective and competitive inhibitor of HMG-CoA reductase, the pivotal enzyme responsible for converting 3-hydroxy-3-methyl glutaryl coenzyme A to mevalonate, a precursor of cholesterol. Its lipid-modifying effects occur through two mechanisms:

1. Enhancement of hepatic LDL receptors, promoting the uptake and breakdown of LDL.
2. Inhibition of hepatic synthesis of VLDL, thereby reducing the total number of VLDL and LDL particles.

Dosage Guidelines

• Recommended daily dose: 5-40 mg, with a 40 mg dosage only for patients failing to achieve LDL-C goals with a 20 mg dose.
• For HoFH: Initiate with 20 mg/day.
• Pediatric Dosage:
  • For HeFH: 5-10 mg/day (age 8 to less than 10 years), 5-20 mg/day (age 10 to 17 years).
  • For HoFH: 20 mg/day (age 7 to 17 years).

Administration

Rosuvastatin can be administered with or without food at any time of the day, as per medical advice.

Drug Interactions

Notable drug interactions include:

• Cyclosporine: Limit Rosuvastatin dose to 5 mg once daily when co-administered.
• Gemfibrozil: Avoid combination or limit Rosuvastatin dose to 10 mg once daily.
• Lopinavir/Ritonavir or atazanavir/ritonavir: Reduce Rosuvastatin dose to 10 mg once daily.
• Coumarin anticoagulants: Monitor INR closely and achieve stability before initiating Rosuvastatin therapy.

Contraindications

Rosuvastatin is contraindicated in individuals with:

• Known hypersensitivity to its components
• Liver disease, including unexplained persistent elevations in hepatic transaminase levels
• Pregnant or breastfeeding women

Side Effects

Rosuvastatin is generally well-tolerated, with common adverse events including headache, myalgia, constipation, asthenia, abdominal pain, and nausea.

Pregnancy & Lactation

The safety of Rosuvastatin in pregnant or breastfeeding women has not been established.

Precautions & Warnings

• Monitor for skeletal muscle effects, liver enzyme abnormalities, especially in elderly patients, those with hypothyroidism or renal impairment, and those on concomitant medications.
• Regularly monitor liver enzymes before and during treatment.

Special Populations

The safety and efficacy of Rosuvastatin in pediatric patients have not been established.

Storage

Store below 30°C, protected from light and moisture, and out of the reach of children.

Chemical Structure

• Molecular Formula: C22H28FN3O6S
• Chemical Structure: [Insert Image/Link to Chemical Structure]

FAQs About Rosuvastatin 10 mg Tablet

[Common questions and answers regarding Rosuvastatin 10 mg Tablet.]

Quick Tips

• Rosuvastatin complements lifestyle modifications in managing high cholesterol.
• Take Rosuvastatin with food to minimize gastrointestinal side effects.
• Inform your doctor of any adverse reactions or changes in health status.
• Regularly monitor liver function, especially in patients with pre-existing conditions.
• Avoid Rosuvastatin during pregnancy, planning pregnancy, or breastfeeding.