Indications
Repres SR serves as a valuable treatment for essential hypertension. It effectively manages hypertension even in patients with compromised renal function, albeit with reduced diuretic impact. Additionally, Repres SR is beneficial for addressing salt and fluid retention linked with congestive heart failure.
Pharmacology
Indapamide, a diuretic antihypertensive, demonstrates vasodilatory effects, likely by impeding the passage of calcium and other ions (sodium, potassium) across cell membranes. Its extra-renal antihypertensive action diminishes vascular hyperreactivity, lowering total peripheral and arteriolar resistance.
Dosage & Administration
Recommended dosage entails one tablet daily, preferably taken in the morning. In more severe cases, combining Indapamide with other antihypertensive agents may be considered. However, its safety and efficacy in pediatric patients remain unestablished.
Interactions
Repres SR may enhance or complement the action of other antihypertensive medications. Additionally, it might decrease arterial responsiveness to norepinephrine. Concomitant use of diuretics like Repres SR with lithium is discouraged due to potential renal clearance reduction and heightened risk of lithium toxicity.
Contraindications
Avoid Repres SR in cases of hypersensitivity to sulfonamides, severe renal failure, hepatic encephalopathy or severe hepatic failure, and hypokalemia.
Side Effects
Possible side effects of Repres SR encompass headache, anorexia, gastric irritation, nausea, vomiting, constipation, and diarrhea.
Pregnancy & Lactation
Due to insufficient data from well-controlled studies, Indapamide is not recommended for pregnant women. Breastfeeding mothers should refrain from taking Indapamide.
Precautions & Warnings
Routine monitoring of potassium and uric acid serum levels is advisable, particularly in individuals predisposed to or sensitive to hypokalemia and those with gout history. Although allergic manifestations were not reported during clinical trials, patients with sulfonamide derivative allergies require close monitoring.
Overdose Effects
Symptoms of overdose may include allergies, skin rashes, epigastric pain, nausea, photosensitivity, dizziness, weakness, and paraesthesia. Treatment involves supportive and symptomatic measures, focusing on correcting electrolyte imbalances.
Therapeutic Class
Repres SR falls under the category of thiazide diuretics and related drugs.
Storage Conditions
Store Repres SR in a cool, dry place, shielded from light and moisture.
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