Prazolok 2

Conditions Prazolok Treats

1. Hypertension: Prazolok effectively treats both essential and secondary hypertension of various causes. It can be used alone or alongside other antihypertensive medications. Notably, it doesn’t compromise renal function.

2. Left Ventricular Failure: Prazolok aids in managing left ventricular failure, particularly when conventional therapies show inadequate response.

3. Raynaud’s Phenomenon and Disease: Prazolok effectively addresses symptoms associated with Raynaud’s phenomenon and disease.

4. Benign Prostatic Hyperplasia (BPH): As an adjunct therapy, Prazolok alleviates urinary obstruction caused by BPH, serving as a valuable pre-surgery treatment.

Pharmacological Insights

Prazolok reduces total peripheral vascular resistance by selectively targeting alpha-1-adrenoreceptors in vascular smooth muscle. It effectively lowers blood pressure without causing rebound hypertension upon cessation.

In congestive heart failure, Prazolok reduces left ventricular filling pressure and improves cardiac output without inducing reflex tachycardia. Additionally, it mitigates the severity and frequency of Raynaud’s attacks and improves urinary symptoms in BPH patients.

Dosage and Administration

Initiating Prazolok therapy with a low starting dose ensures optimal toleration. Dosage adjustments are based on individual patient response, typically observed within one to 14 days.

For hypertension management, gradual dosage increments are recommended until desired blood pressure control is achieved, with potential combination therapy for enhanced efficacy. Similar dose adjustment strategies apply for other conditions like left ventricular failure, Raynaud’s, and BPH.

Prazolok XR Tablet

Extended-release formulations offer convenient once-daily dosing for hypertension management, with gradual dosage titration based on patient response.

Interactions, Contraindications, and Side Effects

Prazolok demonstrates minimal drug interactions, making it suitable for combination therapy with various medications. However, it’s contraindicated in patients with known quinazoline sensitivity.

Common side effects include dizziness, headache, and nausea, which often subside with continued therapy. Caution is advised in pregnancy and lactation, and close monitoring is recommended during therapy initiation for conditions like hypertension, left ventricular failure, and BPH.

Special Populations and Overdose Effects

Prazolok isn’t recommended for children under 12 years old and should be used cautiously in special populations like elderly patients. In cases of overdose, supportive cardiovascular care is paramount, although Prazolok isn’t dialyzable due to its protein-bound nature.

Storage

Store Prazolok away from light and moisture, maintaining temperatures below 30°C, and out of reach of children.