Indications
Phylopen treats infections caused by Gram-positive organisms, including those produced by penicillinase-producing staphylococci. Indicated for various conditions such as skin and soft tissue infections, respiratory tract infections, osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia caused by Phylopen-sensitive organisms, and as prophylaxis during major surgical procedures.
Pharmacology
Flucloxacillin, an isoxazolyl penicillin, inhibits bacterial cell wall formation, particularly against penicillinase-producing staphylococci. Acts as a bactericidal antibiotic by interfering with peptidoglycan synthesis, leading to bacterial cell wall weakening and rupture.
Dosage
Oral administration: Adults typically take 250 mg four times daily, with dosages doubled in severe infections. Children’s doses vary by age. Parenteral administration: Intramuscular or intravenous injections are administered four times daily, with doses adjusted based on severity.
Administration
Oral doses should be taken an hour before meals, as advised by a healthcare professional.
Interaction
Concurrent use may increase Phylopen levels in the blood for extended periods.
Contraindications
Contraindicated in patients with penicillin hypersensitivity.
Side Effects
Common side effects include gastrointestinal disturbances, rashes, urticaria, purpura, fever, and interstitial nephritis.
Pregnancy & Lactation
Classified as US FDA Pregnancy Category B; caution advised during pregnancy and lactation due to excretion in human milk.
Precautions & Warnings
Caution in patients with hepatic dysfunction or allergic diathesis.
Use in Special Populations
Adjustments needed in severe renal failure (creatinine clearance <10 ml/min).
Therapeutic Class
Penicillinase-resistant penicillins.
Reconstitution
For other routes, such as intraarticular or intrapleural, specific doses are dissolved as necessary.
Storage Conditions
Store in a dry, cool place, away from light and heat, and keep out of reach of children.
Brand
Generics
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