Paricel

Indications

Paricel Gastro-resistant Tablets are prescribed for the treatment of:

• Active Duodenal Ulcer
• Active Benign Gastric Ulcer
• Symptomatic Erosive or Ulcerative Gastroesophageal Reflux Disease (GERD)
• Long-term Management of GERD
• Symptomatic Treatment of Moderate to Severe GERD
• Zollinger-Ellison Syndrome
• Eradication of Helicobacter pylori in Peptic Ulcer Disease (in combination with appropriate antibiotics)

Use as directed by a registered healthcare provider.

Pharmacology

Rabeprazole, the active ingredient, reduces stomach acid secretion by inhibiting the H+/K+-ATPase enzyme in gastric parietal cells, effectively acting as a proton pump inhibitor.

Dosage

• Duodenal and Benign Gastric Ulcers: 20 mg once daily, typically in the morning. Treatment duration varies between 4-6 weeks, depending on healing progress.
• Erosive/Ulcerative GERD: 20 mg once daily for 4-8 weeks.
• GERD Maintenance: 20-10 mg once daily, depending on patient response.
• Severe GERD: 10 mg once daily; increase if symptoms persist after 4 weeks.
• Pediatric GERD (1-11 years): 5-10 mg once daily, based on weight.
• Zollinger-Ellison Syndrome: Start with 60 mg daily, adjustable up to 120 mg.
• H. pylori Eradication: 20 mg twice daily combined with clarithromycin and amoxicillin for 7 days.

Consult a healthcare provider for personalized dosing.

Administration

For optimal results, take Paricel tablets in the morning before meals. Do not chew or crush. Tablets should be swallowed whole.

Interactions

Rabeprazole may interact with drugs requiring an acidic environment for absorption, such as ketoconazole. Avoid co-administration with atazanavir. No issues with liquid antacids.

Contraindications

Do not use if allergic to Rabeprazole or any ingredients. Avoid during pregnancy and breastfeeding.

Side Effects

Generally well-tolerated. Possible side effects include headache, nausea, abdominal discomfort, constipation, and dizziness.

Pregnancy & Lactation

Category ‘C’ for pregnancy. Use only if necessary, after evaluating risks and benefits. Likely excreted in breast milk; consider discontinuing breastfeeding or the medication.

Precautions & Warnings

• Exclude gastric or esophageal malignancies before starting treatment.
• Long-term use may increase fracture risk in the elderly.
• Monitor for magnesium levels, especially in long-term use, as deficiency can occur.
• Consider stopping if signs of subacute cutaneous lupus erythematosus (SCLE) appear.
• Not recommended for pediatric use due to insufficient data.

Overdose

Overdose effects are generally minimal and reversible. No specific antidote; treat with supportive care.

Storage

Store below 30°C in a dry place, away from light. Keep out of reach of children.