Olida 100

Indications for Olida

Olida (Sulindac) is a non-steroidal anti-inflammatory drug (NSAID) prescribed for the symptomatic management of various conditions, including:

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis
• Periarticular inflammatory disorders
• Acute painful shoulder
• Acute gouty arthritis
• Diabetic neuropathy
• Diabetic retinopathy

Consult a registered healthcare provider before use.

Pharmacology

Sulindac, the active ingredient in Olida, is a potent NSAID with anti-inflammatory, analgesic, and antipyretic effects. It works primarily by inhibiting prostaglandin synthesis, which is responsible for pain and inflammation. Once absorbed, Sulindac is metabolized into its active form, the sulfide metabolite, which exerts its therapeutic effects.

Dosage & Administration

Olida should be taken orally twice daily with food to reduce gastrointestinal irritation. The maximum recommended dose is 400 mg/day. Below are the recommended starting dosages:

• Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis: Start with 150 mg/day.
• Acute Painful Shoulder & Acute Gouty Arthritis: Start with 200 mg twice daily.

Dosage adjustments should be made according to the patient’s response and tolerability.

Always follow the dosage prescribed by your physician.

Drug Interactions

Olida can interact with various medications and substances:

• Aspirin: Reduces the bioavailability of the active metabolite.
• Paracetamol (Acetaminophen): Prolonged use may increase renal risks.
• Probenecid: May alter Olida’s plasma concentrations.

Patients taking anticoagulants or hypoglycemic drugs should be monitored closely.

Contraindications

Olida should not be used in patients who:

• Are allergic to Sulindac or any of its components.
• Have a history of gastric bleeding or active peptic ulcers.
• Are pregnant (especially in the third trimester) or lactating.
• Have asthma or rhinitis triggered by NSAIDs like Aspirin.

Side Effects

Common side effects include:

• Gastrointestinal: Nausea, abdominal pain, constipation, and bleeding.
• Central Nervous System: Dizziness, drowsiness, headache, and confusion.
• Other effects: Skin rashes, edema, weight gain, tinnitus, and visual disturbances.

Severe allergic reactions may include fever, chills, or jaundice. If these occur, discontinue the medication and seek immediate medical attention.

Pregnancy & Lactation

• Pregnancy: Olida should only be used during the first two trimesters if the benefit outweighs the risk. It is contraindicated during the third trimester.
• Lactation: The excretion of Sulindac in breast milk is unknown. Consult a healthcare professional before using during breastfeeding.

Precautions & Warnings

• Renal impairment: Use with caution in patients with kidney disorders.
• Hepatic impairment: Liver function affects Olida metabolism; dosage adjustments may be necessary.
• Blood disorders: Use cautiously in patients with bleeding disorders or anemia.

Use in Special Populations

• Renal impairment: Monitor closely for kidney function and adjust the dose if necessary.
• Hepatic impairment: Prolonged half-life of Olida may require dose reduction.

Overdose Effects

Overdose symptoms typically involve gastrointestinal, renal, and CNS toxicities. Symptomatic treatment and supportive care are recommended. Seek emergency medical attention if overdose is suspected.

Therapeutic Class

• Osteoarthritis treatment
• Rheumatoid arthritis management
• Gout therapy
• NSAIDs (Non-steroidal Anti-inflammatory Drugs)

Storage Instructions

Store Olida below 25°C, away from moisture and light. Keep it out of reach of children.