Odrel Plus

120.00৳ Strip

  • Reduces the risk of myocardial infarction (MI) and stroke in patients with acute coronary syndrome (ACS), recent MI, or established peripheral arterial disease.
  • Combines Clopidogrel and Aspirin to inhibit platelet aggregation and improve cardiovascular outcomes.
  • Recommended for daily use; administration should follow physician’s advice.
  • Use with caution in patients with certain interactions or contraindications.
Brand

Beximco Pharmaceuticals Ltd

Generics

Clopidogrel + Aspirin

Type

Tablet

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Description

Indications:

  • Acute Coronary Syndrome (ACS): Prescribed to lower the incidence of myocardial infarction (MI) and stroke in patients with non-ST-segment elevation ACS (unstable angina or non-ST-elevation myocardial infarction) and ST-segment elevation ACS (ST-elevation myocardial infarction).
  • Recent MI, Stroke, or Peripheral Arterial Disease: Effective in reducing the risk of MI and stroke in individuals with a history of recent myocardial infarction, recent stroke, or established peripheral arterial disease.

Pharmacology:

  • Clopidogrel: This prodrug inhibits platelet activation and aggregation through irreversible binding to the P2Y12 ADP receptors. Noticeable effects begin within 2 hours of administration, with steady-state inhibition achieved by Day 3 to Day 7.
  • Aspirin: Works by irreversibly inhibiting platelet cyclooxygenase, preventing thromboxane A2 formation, which is crucial for platelet aggregation and vasoconstriction.
  • Pharmacokinetics: Clopidogrel is rapidly absorbed, with peak plasma levels reached about 1 hour post-dose. It is extensively metabolized in the liver. The main metabolite, which does not affect platelet aggregation, constitutes approximately 85% of the drug-related compounds in plasma.

Dosage & Administration:

  • Acute Coronary Syndrome: Begin treatment with a 300 mg loading dose of Clopidogrel, followed by a daily maintenance dose of 75 mg. Combination with Aspirin (75 mg-325 mg daily) is recommended.
  • Recent MI, Stroke, or Peripheral Arterial Disease: Administer 75 mg of Clopidogrel daily, with or without food, without a loading dose.

Interactions:

  • Increased Bleeding Risk: May occur when combined with NSAIDs, warfarin, SSRIs, or SNRIs.
  • CYP2C19 Inhibitors: Avoid using with omeprazole or esomeprazole, as they may impair Clopidogrel’s effectiveness.
  • Repaglinide: Concurrent use is not advised due to increased plasma levels.

Contraindications:

  • Hypersensitivity: To Clopidogrel or any component of the product.
  • Active Pathological Bleeding: Includes conditions like peptic ulcers or intracranial hemorrhage.

Side Effects:

  • Common: Includes bleeding, gastrointestinal discomfort, diarrhea, and skin reactions.
  • Rare: May involve acquired hemophilia, anemia, angioedema, and bone marrow disorders.

Pregnancy & Lactation:

  • Pregnancy: Should be used only if clearly necessary during the first and second trimesters. Contraindicated in the third trimester.
  • Lactation: Clopidogrel’s presence in breast milk is unknown; however, Aspirin is known to be excreted. Discontinue breastfeeding during treatment.

Precautions & Warnings:

  • Bleeding Risk: Prolonged bleeding time is possible.
  • Thrombotic Thrombocytopenic Purpura (TTP): Rarely reported; requires prompt treatment.
  • Reye’s Syndrome: Risk in children with chickenpox or flu-like symptoms.
  • Hypersensitivity: Includes rash, angioedema, or hematologic reactions.

Use in Special Populations:

  • Children: Not recommended, especially under 12 years, due to the risk of Reye’s syndrome.

Overdose Effects:

  • Clopidogrel Overdose: May cause bleeding complications; platelet transfusion might help.
  • Aspirin Overdose: Symptoms include dizziness, headache, and gastrointestinal issues; severe cases may require hemodialysis.

Therapeutic Class:

  • Anti-platelet drugs

Storage Conditions:

  • Store below 30°C, in a cool, dry place, away from light and moisture. Keep out of reach of children.
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