Nexum MUPS 40

Indications

Nexum MUPS tablets serve multiple indications, including:

• Gastro-esophageal Reflux Disease (GERD)
• Reducing the risk of NSAID associated gastric ulcer
• H. pylori eradication (Triple therapy)
• Treatment for Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

Esomeprazole MUPS tablets are available in two strengths:

• Esomeprazole MUPS 20 Tablet: Contains 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)
• Esomeprazole MUPS 40 Tablet: Contains 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP)

Description

MUPS stands for Multiple-Unit Pellet System. This innovative technology combines the advantages of tablets and pellet-filled capsules in one dosage form. It ensures greater bioavailability, uniform drug release, and minimizes the possibility of dose dumping.

Pharmacology

Esomeprazole inhibits gastric acid by blocking the proton pump of the gastric parietal cell. It’s effective for short-term treatment of gastric and duodenal ulcers, as well as in preventing and treating NSAID associated gastric ulcers.

Dosage

Dosage varies depending on the condition being treated, ranging from 20 mg to 80 mg once or twice daily.

Administration

Esomeprazole MUPS tablets should be swallowed whole with liquid. They should not be chewed or crushed. If necessary, they can be dispersed in water and consumed immediately.

Interaction

Nexum MUPS may interact with certain drugs metabolized by CYP2C19. Co-administration with diazepam, for example, may decrease its clearance.

Contraindications

Esomeprazole is contraindicated in individuals with known hypersensitivity to any of the formulation components.

Side Effects

Common adverse events include headache, diarrhea, nausea, abdominal pain, and constipation.

Pregnancy & Lactation

Caution is advised during pregnancy and lactation. It’s unknown if Esomeprazole or its metabolites appear in human breast milk.

Precautions & Warnings

Nexum MUPS should be used cautiously in patients with severe liver dysfunction and severe renal impairment. Long-term use may slightly increase the risk of fractures.

Storage Conditions

Store in a cool, dry place below 25°C, protected from light, and keep out of reach of children.

Chemical Structure

Molecular Formula: C17H19N3O3S

Common Questions about Nexum MUPS 20 mg Tablet

• What is Nexum MUPS 20 mg Tablet used for?
• What are the side effects of Nexum MUPS 20 mg Tablet?
• Can I take Nexum MUPS 20 mg Tablet if I am pregnant or breastfeeding?
• How long does it take for Nexum MUPS 20 mg Tablet to work?

Quick Tips

• Nexum MUPS 20 mg Tablet provides long-lasting relief for various stomach conditions.
• Avoid eating late at night or before bedtime.
• Inform your doctor if you experience persistent symptoms or any concerning side effects.
• Long-term use may affect bone health; ensure adequate intake of calcium and magnesium.