Nervalin CR 165

Indications:

Nervalin CR is prescribed for:

• Neuropathic pain related to diabetic peripheral neuropathy (DPN)
• Postherpetic neuralgia (PHN)
• Adjunctive treatment for partial-onset seizures in patients aged 1 month and older
• Fibromyalgia
• Neuropathic pain due to spinal cord injury

Nervalin CR Tablet Specific Indications:

• Neuropathic pain from diabetic peripheral neuropathy (DPN)
• Postherpetic neuralgia (PHN)

Pharmacology:

Pregabalin, a derivative of the neurotransmitter gamma-aminobutyric acid (GABA), acts by binding to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. Although the exact mechanism is not fully understood, this binding is believed to contribute to Pregabalin’s pain-relieving and anti-seizure effects. Unlike GABA itself, Pregabalin does not directly interact with GABAA, GABAB, or benzodiazepine receptors.

Dosage:

• For Neuropathic Pain (DPN):
  • Adults: Start with 50 mg three times daily, with a maximum of 300 mg/day. Gradually increase to 300 mg/day within a week. For extended-release capsules, begin with 165 mg daily, increasing to 330 mg as needed.
• For Postherpetic Neuralgia (PHN):
  • Adults: Start with 75 mg twice daily or 50 mg three times daily, with a maximum of 300 mg/day. Increase to 600 mg/day if necessary, with extended-release capsules starting at 165 mg daily and increasing up to 660 mg daily.
• For Fibromyalgia:
  • Adults: Begin with 75 mg twice daily, with a possible increase to 450 mg/day based on response and tolerability.
• For Neuropathic Pain from Spinal Cord Injury:
  • Adults: Start with 75 mg twice daily, increasing up to 300 mg/day as needed.

Conversion from Pregabalin Capsules to Pregabalin CR: When switching, take the morning dose of Pregabalin capsules as usual, and start Pregabalin CR after an evening meal. Adjust dosage based on the provided conversion guidelines.

Administration:

Pregabalin is administered orally, with or without food. For CR tablets, take after an evening meal and do not crush or chew. If a dose is missed, take it as soon as possible or at the next scheduled time. Discontinue gradually over at least one week.

Interactions:

Nervalin CR generally does not cause significant pharmacokinetic interactions. No known interactions with food.

Contraindications:

Avoid use in individuals with hypersensitivity to Pregabalin or its components.

Side Effects:

Common side effects include dizziness, drowsiness, dry mouth, swelling, blurred vision, weight gain, and concentration difficulties. In pediatric patients, increased weight and appetite are noted.

Pregnancy & Lactation:

Pregabalin’s safety during pregnancy is not well-studied. It is detected in breast milk, so breastfeeding is not recommended during treatment.

Precautions & Warnings:

Monitor for angioedema, hypersensitivity reactions, and suicidal thoughts. Caution is advised with CNS depressants and in patients with respiratory impairments. Gradually taper off to avoid increased seizure frequency or other adverse effects.

Use in Special Populations:

Safety in pediatric patients for some indications is not established. Use in children under 1 month for seizures is not well-supported.

Overdose Effects:

Symptoms of overdose may include reduced consciousness, agitation, and seizures. No specific antidote exists; supportive care and monitoring are essential.

Therapeutic Class:

Adjunct anti-epileptic and primary anti-epileptic drugs.

Storage Conditions:

Store in a cool, dry place (below 30°C), protected from light and moisture. Keep out of reach of children.