Nebita Plus 5/12.5

Indications

Nebivolol & Hydrochlorothiazide combination is recommended for managing essential hypertension.

Pharmacology

The blend of Nebivolol and Hydrochlorothiazide produces an augmented antihypertensive effect, surpassing the efficacy of either component alone. This combination exhibits mild vasodilatory properties, leading to a reduction in heart rate and blood pressure among hypertensive individuals. Hydrochlorothiazide impacts renal tubular mechanisms, enhancing the excretion of sodium and chloride, consequently reducing plasma volume. Moreover, it stimulates plasma renin activity and aldosterone secretion.

Dosage & Administration

Administer once daily, preferably at a consistent time daily. Not suitable for pediatric use.

Use medication as advised by healthcare professionals.

Interaction

Nebivolol:

• Interaction potential with Class I & III Antiarrhythmics, Calcium channel blockers (Verapamil/Diltiazem), centrally-acting antihypertensives, anaesthetics, antipsychotics, antidepressants, and NSAIDs.

Hydrochlorothiazide:

• Interaction potential with drugs affecting potassium & calcium levels, and NSAIDs.

Concurrent administration with certain medications may heighten the hypotensive effect, potentially causing postural hypotension.

Contraindications

Avoid in cases of hypersensitivity to the active substances, liver function impairment, severe renal insufficiency (Creatinine clearance < 30 ml/min.), bradycardia, and hypotension.

Side Effects

Nebivolol: Headache, dizziness, tiredness, diarrhea, constipation, nausea, etc.

Hydrochlorothiazide: Vertigo, itchiness, rash, increased sensitivity of skin to sunlight, etc.

Pregnancy & Lactation

Not recommended during pregnancy or lactation.

Precautions & Warnings

Nebivolol: Avoid in untreated Congestive Heart Failure (CHF) & bradycardia. Exercise caution in patients with Chronic Obstructive Pulmonary Diseases (COPD).

Hydrochlorothiazide: Monitor renal function, as thiazides may exacerbate azotemia. Watch for fluid or electrolyte imbalances.

Overdose Effects

Data on overdosage are unavailable. Overdosing with Hydrochlorothiazide may lead to electrolyte depletion and dehydration due to excessive diuresis.

Therapeutic Class

Combined antihypertensive preparations.

Storage Conditions

Store below 30°C, protected from light & moisture. Keep out of reach of children.