Moxquin D

Indications

Moxifloxacin and Dexamethasone eye drops are prescribed for treating bacterial eye infections caused by susceptible microorganisms. They are also used to prevent post-surgical inflammation and bacterial infections following eye surgery.
Always follow the advice of a registered healthcare provider.

Composition

Each ml of the eye drop contains:

• Moxifloxacin Hydrochloride BP (equivalent to Moxifloxacin 5 mg)
• Dexamethasone Sodium Phosphate USP (equivalent to Dexamethasone Phosphate 1 mg)

Pharmacology

Moxifloxacin is a potent, broad-spectrum, 4th-generation fluoroquinolone antibiotic. It works by inhibiting the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, both of which are critical for bacterial DNA replication, transcription, and repair. These enzymes also help separate DNA during bacterial cell division.

Dexamethasone is a highly effective corticosteroid due to its unique structure, including a methyl group at the 16-alpha position and a fluorine atom at the 9-alpha position. It has strong anti-inflammatory, anti-allergic, and anti-proliferative properties. Dexamethasone works by inhibiting phospholipase A2, the key enzyme in prostaglandin synthesis, and reduces neutrophil infiltration to inflammation sites.

Dosage & Administration

• Prevention of infection and post-surgical inflammation: Instill 1 drop in the eye, 4 times daily, starting from the day before surgery and continuing for 15 days after surgery.
• Cataract surgery: Instill the eye drop immediately after surgery.
• LASIK surgery: Instill the drop at least 15 minutes post-surgery.
• Eye infections caused by susceptible microorganisms: Instill 1 drop, 4 times daily, for up to 7 days.
  Always use as directed by a registered healthcare professional.

Contraindications

The use of this product is contraindicated in patients with:

• Hypersensitivity to quinolones or any component of the product
• Glaucoma, or any condition leading to thinning of the cornea or sclera
• Viral eye infections (e.g., herpes simplex keratitis, vaccinia, varicella)
• Mycobacterial or fungal infections of the eye

Side Effects

• Moxifloxacin: May cause conjunctivitis, reduced visual acuity, dry eyes, keratitis, ocular discomfort, redness, pain, subconjunctival hemorrhage, and tearing.
• Dexamethasone: May result in vision disturbances, cataracts, secondary infections, or perforation of the globe.

Pregnancy & Lactation

There are no sufficient, well-controlled studies of this combination in pregnant women. The use of Moxifloxacin & Dexamethasone eye drops during pregnancy should be considered only if the potential benefits outweigh the risks. Caution is advised when administering to nursing mothers.

Precautions & Warnings

• Discontinue use and consult a doctor if an allergic reaction to Moxifloxacin occurs.
• Prolonged steroid use may lead to increased intraocular pressure, glaucoma, optic nerve damage, visual defects, or cataracts.
• Use with caution in conditions that cause thinning of the cornea or sclera, as perforation may occur.
• Steroids can mask or worsen infections in acute purulent eye conditions.

Use in Special Populations

• Elderly: No dosage adjustment is required for elderly patients.
• Children: Safety and efficacy in pediatric patients have not been established.

Overdose

Currently, no specific information is available regarding overdose with this product.

Therapeutic Class

Ophthalmic steroid and antibiotic combination preparations.

Storage Conditions

Store below 30°C in a cool, dark place. Once opened, use within 28 days and keep at room temperature. Discard after 28 days. Keep out of reach of children.