Methicol 500

Indications

Methicol tablet serves as a remedy for various conditions, including:

• Peripheral neuropathy
• Diabetic neuropathy
• Alcoholic neuropathy
• Drug-induced neuropathy
• Entrapment neuropathy
• Lumbago
• Intercostal neuralgia
• Diabetic retinopathy
• Multiple sclerosis
• Vertebral syndrome
• Parkinson’s disease
• Alzheimer’s disease
• Bell’s palsy

Methicol Injection is designated for:

• Treating peripheral neuropathies and megaloblastic anemia caused by vitamin B12 deficiency.

Pharmacology

Mecobalamin, a coenzyme form of vitamin B12, plays a crucial role in various biological processes. Unlike cyanocobalamin, it features a methyl group instead of a cyano group at the cobalt. It functions as a cofactor in methionine synthase, facilitating methyl group transfer for homocysteine regeneration into methionine. Moreover, it supports myelin integrity, neuronal function, red blood cell formation, and DNA synthesis. Mecobalamin aids in neuronal lipid synthesis, axonal nerve regeneration, promotes axonal transport, and exhibits neuroprotective properties.

Dosage & Administration

• Tablet: Take 0.5 mg tablet thrice daily after meals. Adjust the dosage based on the patient’s age and symptom severity.
• Injection: For adults with peripheral neuropathies, administer 1 ampoule (500 mcg Mecobalamin) IM or IV three times weekly. Adjust the dose according to age and symptoms. For megaloblastic anemia, administer the same dose regimen for two months, then reduce to a single administration every 1 to 3 months for maintenance therapy. Not recommended for use in children.

Interactions

Certain medications may affect the absorption and serum concentrations of vitamin B12. Caution should be exercised with neomycin, aminosalicylic acid, histamine H2-antagonists, omeprazole, colchicine, and oral contraceptives.

Contraindications

Avoid Methicol if there is hypersensitivity to Mecobalamin or any other components of the formulation.

Side Effects

Adverse effects may include dermatologic reactions such as rash, gastrointestinal disturbances like anorexia, nausea/vomiting, and diarrhea, as well as neurologic effects like headaches. Anaphylactoid reactions, hot sensations, diaphoresis, and injection site pain/induration are also possible. Discontinue treatment if severe symptoms occur.

Pregnancy & Lactation

Data on mecobalamin use during pregnancy and lactation are limited. While vitamin B12 is present in breast milk, its use during breastfeeding is generally considered safe by the American Academy of Pediatrics.

Precautions & Warnings

Avoid prolonged, aimless use of Methicol beyond one month unless effective. Larger doses of Methicol are not recommended for individuals whose occupation involves handling mercury or its compounds.

Therapeutic Class

Methicol belongs to the category of drugs used for treating megaloblastic anemia.

Storage Conditions

Keep Methicol at room temperature, protected from moisture and light.