Mecolagin Chewable Tablet

Indications

Mecolagin Tablet is recommended for:

• Peripheral neuropathy
• Diabetic neuropathy
• Alcoholic neuropathy
• Drug-induced neuropathy
• Entrapment neuropathy
• Lumbago
• Intercostal neuralgia
• Diabetic retinopathy
• Multiple sclerosis
• Vertebral syndrome
• Parkinson’s disease
• Alzheimer’s disease
• Bell’s palsy

Mecolagin Injection is indicated for:

• Treatment of peripheral neuropathies and megaloblastic anemia due to vitamin B12 deficiency.

Consult a registered healthcare professional before use.

Pharmacology

Mecobalamin, a coenzyme form of vitamin B12, plays a vital role in methyl group transfer and the regeneration of methionine from homocysteine. It is essential for maintaining myelin integrity, neuronal function, red blood cell formation, and DNA synthesis. Mecobalamin aids in synthesizing neuronal lipids, regenerating axonal nerves, promoting axonal transport, and providing neuroprotective effects.

Dosage & Administration

• Tablet: Take 0.5 mg three times daily after meals. Adjust the dosage based on the patient’s age and symptom severity.
• Injection:
  • For Peripheral Neuropathies: Adults should receive 1 ampoule (500 mcg) daily via IM or IV, three times a week, with adjustments as needed.
  • For Megaloblastic Anemia: Administer 1 ampoule (500 mcg) daily via IM or IV, three times a week. After 2 months, reduce to one ampoule every 1 to 3 months for maintenance.

Not recommended for children.

Interaction

Vitamin B12 absorption may be hindered by medications such as neomycin, aminosalicylic acid, H2-antagonists, omeprazole, and colchicine. Oral contraceptives can lower serum concentrations, which may be clinically relevant.

Contraindications

Avoid in patients with hypersensitivity to Mecobalamin or any formulation components.

Side Effects

Potential side effects include:

• Dermatologic: Rash (discontinue if symptoms appear)
• Gastrointestinal: Anorexia, nausea, vomiting, diarrhea
• Neurologic: Headache
• Others: Anaphylactoid reactions, hot sensation, diaphoresis, injection site pain or induration

Pregnancy & Lactation

Data on Mecobalamin use during pregnancy and lactation are limited. However, it is generally considered compatible with breastfeeding as vitamin B12 is present in breast milk.

Precautions & Warnings

Mecolagin should not be used beyond one month without efficacy. Prolonged high doses are not recommended for those handling mercury or mercury compounds.

Therapeutic Class

Drugs for megaloblastic anemia.

Storage Conditions

Store at room temperature, protected from moisture and light.