Maxiflox 400

Indications

Maxiflox tablet is prescribed for treating various bacterial infections, including:

• Acute bacterial sinusitis
• Acute exacerbation of chronic bronchitis
• Community-acquired pneumonia
• Uncomplicated & complicated skin and skin structure infections
• Complicated intra-abdominal infections
• Pelvic inflammatory disease

Always use under the guidance of a registered healthcare professional.

Pharmacology

Maxiflox contains Moxifloxacin, a 4th-generation fluoroquinolone antibiotic that offers broad-spectrum coverage against a wide array of bacterial pathogens, including gram-positive, gram-negative, anaerobic, and atypical bacteria like Mycoplasma pneumoniae. Moxifloxacin works by inhibiting essential bacterial enzymes, topoisomerase II and topoisomerase IV, which are involved in DNA replication, transcription, and repair.

Dosage & Administration

For optimal treatment, Maxiflox dosage varies based on the infection:

• Acute bacterial sinusitis: 400 mg once daily for 7-10 days
• Acute bacterial exacerbation of chronic bronchitis: 400 mg once daily for 5-10 days
• Community-acquired pneumonia: 400 mg once daily for 7-14 days
• Uncomplicated skin infections: 400 mg once daily for 7 days
• Complicated skin infections: 400 mg once daily for 7-21 days
• Complicated intra-abdominal infections: 400 mg once daily for 5-14 days
• Pelvic inflammatory disease: 400 mg once daily for 14 days

Dosage must be adjusted as per the advice of a registered healthcare provider.

Interaction

• Decreased absorption: Maxiflox’s absorption is reduced when taken with antacids, sucralfate, multivitamins, and multivalent cations like iron or zinc.
• Drug interactions: The use of Maxiflox alongside NSAIDs may increase the risk of seizures, while it can enhance bleeding risk when used with warfarin. Avoid combining Maxiflox with these medications.

Contraindications

• Hypersensitivity to Moxifloxacin or any other quinolone antibiotics.
• Contraindicated in patients with a prolonged QT interval, uncorrected hypokalemia, or those receiving antiarrhythmic agents (Class IA or III).

Side Effects

Common side effects may include:

• Nausea, vomiting, and diarrhea
• Headache and dizziness

Pregnancy & Lactation

Maxiflox is classified as FDA pregnancy category C. It is not recommended during pregnancy or lactation due to potential risks.

Precautions & Warnings

• Tendon risk: Maxiflox has been associated with tendonitis and tendon rupture. Discontinue the medication if pain or inflammation in a tendon occurs.
• QT interval prolongation: Use with caution in patients with a history of QT prolongation or those on antiarrhythmic drugs.
• Electrolyte imbalances: Avoid use in patients with uncorrected hypokalemia.

Use in Special Populations

• Renal or hepatic impairment: No dosage adjustment is required for patients with renal or hepatic dysfunction.
• Pediatric patients: Safety and efficacy have not been established in children or adolescents under 18 years of age.

Therapeutic Class

• 4-Quinolone preparations

Storage Conditions

Store Maxiflox tablets in a cool, dry place, away from light and heat. Keep out of the reach of children.