Lutisone Nasal Spray

Indications

Lutisone is recommended for:

• Preventing and treating seasonal allergic rhinitis, including hay fever, as well as perennial rhinitis.
• It exhibits strong anti-inflammatory effects on the nasal mucosa with minimal systemic activity.

Use as directed by a registered physician.

Description

Lutisone is a synthetic corticosteroid with trifluorinated properties, offering significant anti-inflammatory benefits. It is available as an aqueous suspension of microfine Lutisone, specifically designed for topical nasal application using a metered, atomizing spray pump. Each bottle delivers 120 precise sprays.

Pharmacology

When applied topically to the nasal mucosa, Fluticasone Propionate triggers both anti-inflammatory and vasoconstrictor effects. The exact mechanism is not fully understood but may involve reducing the number of mediator cells (basophils, leukocytes, and mast cells) at the epithelial level, decreasing eosinophil counts, desensitizing sensory nerves to stimuli, controlling secretory responses to cholinergic stimulation, and minimizing fibroblast activity. Other possible mechanisms include inhibiting capillary dilation and permeability, stabilizing lysosomal membranes, and preventing the release of proteolytic enzymes.

Dosage

• Adults and children over 12 years: Administer 2 sprays in each nostril once daily, preferably in the morning. In some cases, 2 sprays twice daily may be needed, not exceeding a total of 4 sprays.
• Children aged 4-11 years: Administer 1 spray in each nostril once daily, with a maximum of 4 sprays per day. For perennial rhinitis in this age group, clinical data is insufficient for a formal recommendation.
• Children under 4 years: The safety and efficacy of Fluticasone Propionate nasal spray in children under 4 years have not been established.

For optimal results, use Fluticasone Propionate Nasal Spray at regular intervals as prescribed by a healthcare provider.

Use as directed by a registered physician.

Administration Instructions

To use Lutisone Nasal Spray:

1. Gently shake the bottle and remove the dust cover.
2. Hold the spray bottle with your forefinger and middle finger on either side of the nozzle, and your thumb beneath the bottle. Press down until a fine mist appears. If the spray is unused for a week or longer, press several times until a fine mist is released.
3. Blow your nose gently to clear your nostrils.
4. Close one nostril, insert the spray nozzle into the other nostril, tilt your head slightly forward, and keep the bottle upright. While breathing in through your nose, press the nozzle to release one spray.
5. Breathe out through your mouth.
6. Repeat the process for the second nostril.

Cleaning Instructions: Clean the nasal spray at least once per week:

1. Remove the dust cover.
2. Gently detach the nasal applicator.
3. Wash the applicator and dust cover with warm water.
4. Shake off excess water and allow to air dry. Avoid using additional heat.
5. Reattach the applicator and replace the dust cover.

Use as directed by a registered physician.

Contraindications

Lutisone Nasal Spray is not recommended for patients with known hypersensitivity to any of its components.

Side Effects

Due to minimal absorption into the body, side effects are rare. However, potential effects include nasal or throat dryness, an unpleasant taste or smell, and an increased likelihood of nosebleeds.

Pregnancy and Lactation

There are no adequate, controlled studies on the use of Fluticasone Propionate in pregnant women. It should only be used during pregnancy if the benefits outweigh the risks. It’s unknown if Fluticasone Propionate is excreted in breast milk, though other corticosteroids have been detected in breast milk. Use caution if administering to nursing mothers.

Precautions and Warnings

Rare instances of wheezing, nasal septum perforation, cataracts, glaucoma, and increased intraocular pressure have been reported with intranasal corticosteroids, including Lutisone. Although systemic effects are minimal at recommended doses, risks may increase with higher doses. Avoid exceeding the recommended dosage.

Therapeutic Class

Fluocinolone & Combined Preparations, Nasal Steroid Preparations.

Storage

Keep out of reach of children. Store in a cool, dry place, protected from light.