Lutisone 0.005%

50.00৳ Ointment

  • Lutisone is a topical medication containing Fluticasone propionate, effective for treating inflammatory and itchy conditions associated with eczema and dermatitis.
  • It features a strong anti-inflammatory action with minimal systemic absorption, making it suitable for various skin types.
  • Recommended application includes a thin layer once daily for cream and twice daily for ointment.
  • Consult a registered physician before use to ensure safety and efficacy.
Brand

Incepta Pharmaceuticals Ltd

Generics

Fluticasone Propionate

Type

Ointment

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Description

Indications

Lutisone is recommended for alleviating inflammatory and itchy conditions associated with eczema and dermatitis that respond to corticosteroid treatment.
Note: Use this medication as directed by a registered physician.

Pharmacology

Fluticasone propionate is a potent glucocorticoid known for its strong topical anti-inflammatory properties and minimal HPA-axis suppression when applied to the skin. This results in a superior therapeutic index compared to many commonly used steroids. Fluticasone propionate selectively binds to glucocorticoid receptors, exhibiting a robust affinity and agonist activity at human glucocorticoid receptors. These receptors play a crucial role in the anti-inflammatory effects of glucocorticoids. Notably, fluticasone has a weak affinity for progesterone receptors and almost no interaction with mineralocorticoid, estrogen, or androgen receptors. The therapeutic efficacy of glucocorticoids is linked to the half-life of the glucocorticoid-receptor complex, which for fluticasone propionate is approximately 10 hours.

Dosage & Administration

  • Cream: Apply a thin layer of fluticasone propionate cream to the affected areas of skin once daily.
  • Ointment: Apply a thin layer of fluticasone propionate ointment to the affected skin areas twice daily.
    Note: Use this medication as directed by a registered physician.

Interactions

Currently, there is no available information on interactions.

Contraindications

Fluticasone propionate should not be used in the following conditions:

  • Rosacea
  • Acne vulgaris
  • Perioral dermatitis
  • Primary cutaneous viral infections (e.g., herpes simplex, chickenpox)
  • Hypersensitivity to any ingredient
  • Perianal and genital pruritus

This medication is also not indicated for treating primarily infected skin lesions caused by fungal or bacterial infections and is contraindicated in children under one year of age, including those with dermatitis and diaper rashes.

Side Effects

Lutisone is generally well tolerated, though some users may experience local burning or itching. If any signs of hypersensitivity occur, discontinue use immediately. Prolonged use of potent corticosteroid preparations may lead to local skin changes such as thinning, striae, dilated superficial blood vessels, hypertrichosis, and hypopigmentation.

Secondary infections can arise, particularly with occlusive dressings or skin folds, and allergic contact dermatitis has also been reported. Exacerbation of dermatological conditions can occur with corticosteroid use.

Extended application of large quantities or treatment of extensive areas may lead to systemic absorption, resulting in symptoms of hypercorticism, especially in infants and children, particularly when using occlusive dressings. In infants, diapers can act as occlusive dressings.

Pregnancy & Lactation

The use of fluticasone propionate during pregnancy should only be considered if the expected benefits to the mother outweigh any potential risks to the fetus. The transfer of fluticasone propionate into breast milk has not been studied. However, plasma levels following dermal application at recommended doses are likely to be low. When used in breastfeeding mothers, weigh the therapeutic benefits against potential risks to both the mother and child.

Precautions & Warnings

Although Lutisone has minimal systemic absorption, prolonged use of high doses on large areas—especially in infants and young children—may lead to adrenal suppression. Children are more susceptible to systemic toxicity from topical corticosteroids due to proportionally larger absorption. The facial area, in particular, may experience atrophic changes after extended treatment with strong topical corticosteroids. This consideration is crucial when treating severe eczema. Use appropriate antimicrobial therapy for inflammatory lesions that become infected. If any infection spreads, cease topical corticosteroid therapy and initiate systemic antimicrobial treatment. Bacterial infections can be exacerbated by the warm, moist conditions created by occlusive dressings; therefore, ensure the skin is cleansed before applying a fresh dressing.

Overdose Effects

Acute overdose is highly unlikely. However, in cases of chronic misuse, symptoms of hypercorticism may develop, and treatment should be discontinued. It is extremely unlikely to experience an overdose from ingesting Lutisone cream or ointment due to its very low oral bioavailability.

Therapeutic Class

Topical preparations containing Fluticasone and other combined agents.

Storage Conditions

Store below 30°C. Do not freeze.

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