Luraprex 40

Indications

Luraprex, an atypical antipsychotic, is prescribed for treating various conditions, including:

• Schizophrenia
• Depressive episodes associated with Bipolar I Disorder (bipolar depression), both as monotherapy and in combination with lithium or valproate.

Pharmacology

The efficacy of Lurasidone in treating schizophrenia may involve its action as a central Dopamine D2 and Serotonin 5HT2A receptor antagonist.

Dosage & Administration

For Schizophrenia:

• Initial Dose: 40 mg once daily
• Recommended Range: 40 mg to 160 mg once daily

For Bipolar Depression:

• Initial Dose: 20 mg once daily
• Recommended Range: 20 mg to 120 mg once daily

Lurasidone should be taken with food to enhance absorption. Following a healthcare provider’s advice is crucial.

Interactions

When using Luraprex concurrently with moderate inhibitors of CYP3A4 (such as Diltiazem, Atazanavir, Erythromycin, Fluconazole, Verapamil, etc.), the dose should be halved. Avoid grapefruit and grapefruit juice as they may inhibit CYP3A4, affecting Luraprex concentrations.

Contraindications

Avoid Luraprex if there’s hypersensitivity or concurrent administration of strong CYP3A4 inhibitors (e.g., Ketoconazole) or inducers (e.g., Rifampin). Also contraindicated in dementia-related psychosis.

Side Effects

Common side effects include somnolence, akathisia, extrapyramidal symptoms, and nausea.

Pregnancy & Lactation

Lurasidone is categorized as Pregnancy Category B. Its use during pregnancy requires careful consideration of benefits versus risks. Breastfeeding while on Lurasidone should be avoided.

Precautions & Warnings

• Elderly patients with dementia-related psychosis may have an increased risk of cerebrovascular adverse events.
• Immediate discontinuation and close monitoring are advised for neuroleptic malignant syndrome.
• Tardive dyskinesia should prompt discontinuation if clinically appropriate.
• Metabolic changes, hyperglycemia, dyslipidemia, and weight gain are potential concerns.
• Hyperprolactinemia and hematologic abnormalities should be monitored.
• Orthostatic hypotension and syncope risk may necessitate cautious titration.

Use in Special

Populations For patients with moderate to severe renal impairment, adjust the starting dose accordingly. Similarly, in cases of moderate to severe hepatic impairment, dose adjustments are necessary.

Therapeutic Class

Luraprex belongs to the class of atypical neuroleptic drugs.

Storage Conditions

Store Luraprex below 30°C, protected from light and moisture, and out of children’s reach.