Iventi

Indications

The ophthalmic solution is indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of various organisms, including Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae. Additionally, it serves as a highly effective intraocular antibiotic to prevent postoperative bacterial endophthalmitis.

Pharmacology

The antimicrobial action of Moxifloxacin in Iventi results from inhibition of topoisomerase II (DNA gyrase) and topoisomerase IV, crucial enzymes involved in bacterial DNA replication, transcription, and repair.

Dosage & Administration

For eye drops: Administer one drop in the affected eye three times daily for 7 days. For eye ointment: Apply thinly and evenly to the affected eye three times a day for the first two days, then two times a day for the next five days, or as directed by a physician. For intraocular injection: Administer 0.2-0.4 ml dose prior to ocular surgery, with the final dose determined by the doctor.

Interaction

Drug-drug interaction studies have not been conducted with Iventi ophthalmic solution.

Contraindications

Moxifloxacin Hydrochloride ophthalmic solution is contraindicated in patients with a history of hypersensitivity to Moxifloxacin, to other quinolones, or to any of the components in this medication.

Side Effects

The most frequently reported ocular adverse events were conjunctivitis, decreased visual acuity, dry eye, keratitis, ocular discomfort, ocular hyperemia, ocular pain, ocular pruritus, subconjunctival hemorrhage, and tearing. These events occurred in approximately 1-6% of patients. Nonocular adverse events reported at a rate of 1-4% were fever, increased cough, infection, otitis media, pharyngitis, rash, and rhinitis.

Pregnancy & Lactation

Since there are no adequate and well-controlled studies in pregnant women, Moxifloxacin Hydrochloride ophthalmic solution should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Moxifloxacin has not been measured in human milk, although it can be presumed to be excreted in human milk. Caution should be exercised when Moxifloxacin hydrochloride ophthalmic solution is administered to a nursing mother.

Precautions & Warnings

As with other anti-infectives, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, discontinue use and institute alternative therapy. Whenever clinical judgment dictates, the patient should be examined with the aid of magnification, such as slit lamp biomicroscopy, and, where appropriate, fluorescein staining. Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis.

Therapeutic Class

Ophthalmic antibacterial drugs

Storage Conditions

Store bellow 25°C. Do not freeze. Store in cool and dry place, protected from light. Keep out of the reach of children. Do not touch dropper tip to any surface as this may contaminate Iventi. Do not use after one month of first opening.