Indications
Used for treating oropharyngeal candidiasis, vulvovaginal candidiasis, pityriasis versicolor, tinea pedis, tinea cruris, tinea corporis, tinea manuum, onychomycosis, and histoplasmosis. Also indicated for systemic candidiasis, aspergillosis, cryptococcosis, and maintenance therapy in AIDS patients.
Pharmacology
Inhibits Cytochrome P-450 dependent enzymes, impairing ergosterol biosynthesis crucial for fungal cell membranes. Utilizes SUBA (Super Bio-available) technology for enhanced bioavailability.
Dosage & Administration
The dosage and administration of Itraconazole vary depending on the specific fungal infection being treated. It is available in different strengths, including 100 mg, 130 mg, and 200 mg capsules. The duration of treatment also varies based on the severity and type of infection, as well as the patient’s response to therapy.
For non-systemic fungal diseases such as vulvovaginal candidiasis, pityriasis versicolor, tinea corporis, tinea cruris, tinea pedis, tinea manuum, and oropharyngeal candidiasis, the recommended dosage ranges from 65 mg to 200 mg per day. Treatment durations typically range from 1 day to 30 days, depending on the condition being treated.
For systemic fungal diseases such as aspergillosis, candidiasis, cryptococcosis, and histoplasmosis, the recommended dosage is generally higher, ranging from 65 mg to 200 mg twice daily. The duration of treatment for systemic fungal infections can vary significantly, ranging from several weeks to several months, and may require adjustments based on the patient’s response to therapy.
It’s essential to follow the dosage instructions provided by your healthcare provider or pharmacist carefully. Do not exceed the recommended dosage or duration of treatment without consulting your healthcare provider. Additionally, always take Itraconazole capsules with a full meal to enhance absorption and minimize the risk of gastrointestinal side effects.
If you have any questions or concerns about the appropriate dosage and administration of Itraconazole for your specific condition, be sure to consult your healthcare provider for personalized advice and guidance.
Interaction
Avoid concurrent use with specific drugs like terfenadine, astemizole, and cisapride.
Contraindications
Contraindicated in patients with known hypersensitivity or severe hepatic disease.
Side Effects
Nausea, abdominal pain, headache, raised liver enzymes, menstrual disorders, allergic reactions, peripheral neuropathy, among others.
Pregnancy & Lactation
Contraindicated in pregnancy; not recommended during breastfeeding.
Precautions & Warnings
Monitor liver function during prolonged use; administer with caution in patients with reduced gastric acidity.
Therapeutic Class
Drugs for subcutaneous and mycoses.
Storage Conditions
Store below 25°C in a cool, dry place; keep away from light and children.
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