Hypnofast 7.5

Indications

Hypnofast is prescribed for:

• Short-term management of insomnia.
• Sedation prior to surgical or diagnostic procedures.

Use only under the guidance of a registered healthcare professional.

Description

Hypnofast is a sleep-inducing medication known for its rapid onset and short duration of action. It also provides anxiolytic, anticonvulsant, and muscle-relaxant effects.

Pharmacology

Benzodiazepines like midazolam function by enhancing the action of gamma-aminobutyric acid (GABA), a key inhibitory neurotransmitter in the central nervous system. By increasing GABA activity, benzodiazepines induce sedation, relax skeletal muscles, and promote sleep, anesthesia, and amnesia. These drugs bind to the benzodiazepine site on GABA-A receptors, enhancing the effects of GABA by increasing the frequency of chloride channel openings. While these receptors are found in various tissues, they are predominantly present in the central nervous system.

Dosage & Administration

Oral Dosage:

• Adults: 7.5-15 mg daily.
• Elderly and Debilitated Patients: Recommended dose is 7.5 mg.
• Premedication: Administer 15 mg of Midazolam 30-60 minutes prior to the procedure.

Intravenous Administration:

• Endoscopic or Cardiovascular Procedures: Initial dose of approximately 2.5 mg for healthy adults; reduce to 1-1.5 mg for elderly or severely ill patients.
• Induction of Anesthesia: Dose of 10-15 mg.

Intramuscular Administration:

• Adults: 0.07-0.1 mg/kg body weight; typical dose is about 5 mg.
• Children: 0.15-0.20 mg/kg.
• Elderly and Debilitated Patients: 0.025-0.05 mg/kg.

Rectal Administration for Children:

• Preoperative Sedation: Administer 0.35-0.45 mg/kg rectally 20-30 minutes before general anesthesia induction.

Use only under the guidance of a registered healthcare professional.

Interaction

Hypnofast may enhance the sedative effects of neuroleptics, tranquilizers, antidepressants, sleep aids, analgesics, anesthetics, antipsychotics, anxiolytics, antiepileptic drugs, and sedative antihistamines.

Contraindications

Midazolam is contraindicated in patients with severe respiratory insufficiency, severe hepatic insufficiency, myasthenia gravis, sleep apnea syndrome, or known hypersensitivity to benzodiazepines or any component of the product.

Side Effects

Initial side effects may include daytime drowsiness, confusion, fatigue, headache, and muscle weakness, which typically resolve with continued use. Following parenteral administration, fluctuations in vital signs, including respiratory depression, apnea, and variations in blood pressure and pulse rate, may occur.

Pregnancy & Lactation

Midazolam should be avoided during pregnancy unless no safer alternative is available. It is also excreted in breast milk and should not be given to breastfeeding mothers.

Precautions & Warnings

Administer Hypnofast IV very slowly to avoid complications.

Overdose Effects

Severe overdose can lead to coma, areflexia, cardiorespiratory depression, and apnea. Overdose effects can be managed with the benzodiazepine antagonist flumazenil.

Therapeutic Class

Benzodiazepine hypnotics, Benzodiazepine sedatives.

Storage Conditions

Store in a cool, dry place, protected from light and moisture. Keep out of reach of children.