Glipita 50

Indications

• Glipita is prescribed as an adjunct to diet and exercise to enhance glycemic control in adults with type 2 diabetes mellitus.
• Important Note: Glipita is not suitable for individuals with type 1 diabetes or diabetic ketoacidosis and has not been evaluated for patients with a history of pancreatitis.

Pharmacology

Glipita contains Sitagliptin, a DPP-4 inhibitor. It enhances the action of incretin hormones by preventing their breakdown, leading to increased insulin release and reduced glucagon levels, thereby improving blood sugar control.

Dosage & Administration

• Adults & Adolescents (12+ years): 50 mg twice daily or 100 mg once daily, with or without food.
• Children (2-11 years):
  • Weighing 25 kg or more: 5 ml of oral solution daily.
  • Weighing 10-24 kg: 2.5 ml of oral solution daily.

Interactions

• Drug Interactions: Monitor when used with ketoconazole, erythromycin, or CYP3A4 inhibitors. No major interactions with metformin, glyburide, or other common drugs.
• Food Interactions: Avoid grapefruit and grapefruit juice.

Contraindications

• Hypersensitivity to Sitagliptin or any excipients.

Side Effects

• Common: Headache, upper respiratory infections, nasopharyngitis.
• Rare: Palpitations, tachycardia.

Pregnancy & Lactation

• Pregnancy Category B: Use only if necessary. Caution is advised during lactation as the drug may be excreted in milk.

Precautions & Warnings

• Pancreatitis: Discontinue if pancreatitis is suspected.
• Renal Insufficiency: Adjust dosage based on renal function.
• Hypoglycemia Risk: May require dose adjustment when used with sulfonylureas or insulin.

Special Populations

• Elderly: Use with caution due to potential renal function decline.
• Pediatric: Safety and effectiveness not established for those under 18.
• Renal Insufficiency: Dosage adjustments required for moderate to severe cases.

Overdose Effects

• Symptoms: Mostly mild, such as somnolence. Supportive care recommended. Glipita is modestly dialyzable.

Therapeutic Class

• Dipeptidyl Peptidase-4 (DPP-4) Inhibitor

Storage Conditions

Store below 25°C, away from light and moisture. Keep out of reach of children and do not use past the expiry date.