Gastalfet 200ml

Indications

Gastalfet is prescribed for the treatment and prevention of:

• Duodenal ulcers
• Gastric ulcers
• Chronic gastritis
• Prophylaxis of gastrointestinal bleeding from stress ulcers in critically ill patients

Pharmacology

Gastalfet contains Sucralfate, a non-systemic agent minimally absorbed from the gastrointestinal tract. It forms a protective barrier at ulcer sites, aiding in the healing of gastric and duodenal ulcers. Additionally, Sucralfate inhibits pepsin and bile activity, enhancing ulcer protection.

Dosage

• For Duodenal Ulcers, Gastric Ulcers, and Chronic Gastritis:
  • Adults: 2 gm twice daily on rising and at bedtime, or 1 gm four times a day, one hour before meals and at bedtime. Maximum dose is 8 gm daily, up to twelve weeks if necessary.
  • Pediatric Population: Safety and efficacy in children under 14 years are not established.
  • Elderly: No special dosage adjustments are required, but use the lowest effective dose.
• For Prophylaxis of Stress Ulceration:
  • Adults: 1 gm orally or via a nasogastric tube 4 to 6 times daily. To prevent tube clogging, flush with 10 ml of water after each dose. Duration of use should be individualized but generally not exceed 14 days.

Note: Follow your healthcare provider’s instructions.

Administration

Take Gastalfet on an empty stomach. Avoid administering antacids within 30 minutes of taking Gastalfet.

Interactions

Gastalfet may reduce the absorption of various drugs such as Fluoroquinolones, Tetracycline, and Ketoconazole. To mitigate this, separate the administration of these drugs by at least two hours. Avoid co-administration with citrate preparations due to potential increased aluminum absorption.

Contraindications

Do not use if hypersensitive to Sucralfate.

Side Effects

Common side effects include headache, nausea, abdominal pain, constipation, diarrhea, and urticaria. Rarely, bezoar formation and hyperglycemia in diabetic patients may occur.

Pregnancy & Lactation

Use during pregnancy only if clearly necessary. It is unknown if Sucralfate is excreted in breast milk, so exercise caution when administering to breastfeeding women.

Precautions & Warnings

Use Gastalfet cautiously in patients with renal impairment due to the risk of aluminum accumulation. It is not recommended for individuals on dialysis or with severe renal conditions. Monitor renal function and avoid other aluminum-containing medications.

Use in Special Populations

• Pediatric Population: Not recommended for children under 14 years.
• Elderly: No special adjustments needed.
• Renal Impairment: Use with caution in patients with renal insufficiency.
• Driving & Operating Machinery: Avoid driving if experiencing dizziness or drowsiness.

Overdose Effects

Most cases of overdose remain asymptomatic, but symptoms like abdominal pain, nausea, and vomiting may occur. Risks associated with overdose are minimal.

Therapeutic Class

Chelating Complex

Storage Conditions

Store in a cool, dry place, away from light.