Gabapen 300

Indications

Gabapen is primarily indicated for the following conditions:

• Neuropathic Pain: Effective in alleviating pain resulting from nerve damage.
• Adjunctive Therapy for Seizures: Utilized as an additional treatment for partial seizures and secondary generalized seizures.

Always consult a registered healthcare professional before using this medication.

Pharmacology

Gabapentin is classified as an anti-convulsant and serves as a structural analog of gamma-aminobutyric acid (GABA). Its pharmacological effects arise from the activity of the drug itself. Gabapentin works by binding to the alpha-2-delta subunit of voltage-gated L-type calcium channels, inhibiting branched-chain amino acid transferase, and likely reducing the release of excitatory neurotransmitters.

Dosage

Neuropathic Pain:

• Begin treatment with a single dose of 300 mg on Day 1.
• Increase to 300 mg twice daily on Day 2.
• Continue with 300 mg three times daily on Day 3.
• The dosage can then be adjusted as needed, with a maximum daily dosage of 1800 mg (divided into three doses).

Epilepsy:

• Patients Over 12 Years: The effective dosage ranges from 900 to 1800 mg per day, divided into three doses. Start with 300 mg three times a day.
• Pediatric Patients Aged 3-12 Years: Initiate treatment with a dose of 10-15 mg/kg/day, divided into three doses, gradually increasing over approximately three days to achieve an effective dose.

Always consult a registered healthcare professional before using this medication.

Administration

Gabapentin can be taken orally, either with or without food, providing flexibility in administration.

Always consult a registered healthcare professional before using this medication.

Interactions

Certain medications may influence the effectiveness of Gabapen. For instance, antacids can decrease its bioavailability by up to 20%. Cimetidine may affect its renal excretion. Notably, Gabapen does not interact adversely with other anti-epileptic drugs or oral contraceptives.

Contraindications

Gabapentin is contraindicated for individuals with a known hypersensitivity to the drug.

Side Effects

Common side effects associated with Gabapentin may include:

• Fatigue
• Dizziness
• Ataxia (loss of coordination)
• Weight gain
• Peripheral edema (swelling of extremities)
• Dry mouth
• Somnolence (drowsiness)

Pregnancy & Lactation

Gabapentin is classified as a Category C medication. It should only be used during pregnancy if the potential benefits justify the risks to the fetus. Additionally, Gabapentin can be secreted in breast milk, so its use during lactation should be considered carefully against potential risks to the infant.

Precautions & Warnings

Patients must be advised to take Gabapen strictly as prescribed. It is important to avoid driving or operating heavy machinery until they are aware of how the medication affects their mental and motor skills.

Use in Special Populations

In patients with renal impairment, it is essential to adjust the dosage of Gabapen accordingly to prevent adverse effects.

Therapeutic Class

Gabapentin is categorized as an adjunctive anti-epileptic drug.

Storage Conditions

Store Gabapen below 25°C, shielding it from light and moisture. Keep this and all medications out of reach of children.