Fosamin 3

Indications

Fosfomycin is specifically indicated for the treatment of uncomplicated urinary tract infections (acute cystitis) in women, primarily caused by susceptible strains of Escherichia coli and Enterococcus faecalis.
Always consult a registered healthcare professional before using this medication.

Pharmacology

Fosfomycin exhibits in vitro effectiveness against a wide array of both gram-positive and gram-negative aerobic bacteria associated with uncomplicated urinary tract infections. As a phosphonic acid derivative, Fosfomycin Trometamol is a synthetic, broad-spectrum bactericidal antibiotic designed for oral use. Its bactericidal mechanism involves the inhibition of the enzyme enolpyruvyl transferase, which irreversibly prevents the condensation of uridine diphosphate N-acetylglucosamine with p-enolpyruvate, a crucial step in the synthesis of bacterial cell walls.

Dosage & Administration

For women aged 18 years and older suffering from acute cystitis, the recommended dosage is one sachet of Fosfomycin, which can be taken with or without food. This medication is not intended for use in children.

Preparation: Begin by pouring 100 ml of purified water into a glass. Next, add the entire contents of one Fosfomycin sachet into the water and stir until completely dissolved. Consume the entire mixture immediately after preparation.
Always consult a registered healthcare professional before using this medication.

Interaction

Concurrent use of Fosamin with metoclopramide, which enhances gastrointestinal motility, may reduce serum levels and urinary excretion of fosfomycin. Other medications that increase gastrointestinal motility may exhibit similar effects.

Contraindications

Fosfomycin is contraindicated in individuals with known hypersensitivity to the drug, those with severe renal insufficiency, and patients undergoing hemodialysis.

Side Effects

In clinical trials, the most commonly reported side effects occurring in more than 1% of participants included diarrhea (10.4%), headache (10.3%), vaginitis (7.6%), nausea (5.2%), rhinitis (4.5%), back pain (3.0%), dysmenorrhea (2.6%), pharyngitis (2.5%), dizziness (2.3%), and abdominal pain (2.2%). Other side effects reported at rates below 1% included abnormal stools, anorexia, constipation, dry mouth, dysuria, fever, and more.

Pregnancy & Lactation

Fosfomycin is classified as pregnancy category B. This medication should only be used during pregnancy if the benefits outweigh the risks. Decisions regarding the discontinuation of breastfeeding or the administration of this drug should consider the importance of treatment to the mother.

Precautions & Warnings

Clostridium difficile-associated diarrhea (CDAD) has been linked to the use of nearly all antibacterial agents, including Fosamin. Antibiotic treatments can disrupt the normal flora of the colon, allowing for the overgrowth of C. difficile. It is advised not to exceed a single dose of Fosamin for the treatment of acute cystitis. Multiple daily doses have not shown improved clinical outcomes or eradication rates and may increase the incidence of side effects.

Overdose Effects

When Fosamin is coadministered with metoclopramide, gastrointestinal motility may increase, resulting in reduced serum levels and urinary excretion of fosfomycin. Similar effects may occur with other drugs that enhance gastrointestinal motility.

Therapeutic Class

Intracellular antibiotic

Storage Conditions

Keep out of reach of children. Store in a cool, dry place, below 25°C, and protect from light.