Dinogest 2
500.00৳ Strip
- Dinogest is a progestin medication used to manage endometriosis by alleviating pelvic pain and reducing the growth effects of estrogen on the uterine lining.
- It acts as a selective progesterone receptor agonist, promoting endometrial atrophy and reducing estradiol levels.
- Dinogest is taken daily without breaks, with dosing adjustments for missed or replaced doses.
- It should not be used during pregnancy or lactation without careful consideration of risks.
Brand
|
Beximco Pharmaceuticals Ltd |
|---|---|
Generics
|
Dienogest |
Type
|
Tablet |
Indications
Dinogest is prescribed for managing endometriosis. It belongs to the progestin class of medications, which mitigate the effects of estrogen on the endometrium (uterine lining) and breast tissue. By reducing estrogen’s influence, Dinogest alleviates pelvic pain associated with endometriosis.
Pharmacology
Dinogest, a progestin with strong effects on the endometrium, functions as a selective progesterone receptor agonist. It induces endometrial atrophy, reduces endogenous estradiol levels, and counteracts estrogen’s effects on both normal and ectopic endometrial tissues. It also alleviates androgenic symptoms like acne and hirsutism.
Dosage & Administration
- Tablets: Start any day of the menstrual cycle. Take 2 mg daily without breaks, ideally at the same time each day. Continue without interruption and replace missed doses with an additional 2 mg.
- Missed Doses: If a tablet is missed, take 2 mg as soon as possible and resume normal dosing the next day. Replace doses missed due to vomiting or diarrhea with an additional 2 mg.
Interactions
Dinogest is metabolized by CYP3A4. Drugs that affect CYP3A4 levels, such as certain antifungals, antibiotics, and protease inhibitors, may alter Dinogest’s effectiveness.
Contraindications
Avoid Dinogest in individuals with hypersensitivity to the medication or its components, active venous thromboembolic disorders, severe cardiovascular disease, diabetes with vascular issues, severe hepatic disease, liver tumors, hormone-dependent malignancies, or undiagnosed vaginal bleeding.
Side Effects
Common side effects include headache, breast discomfort, mood changes, and acne. Less frequent effects may involve gastrointestinal disturbances, weight increase, and mood alterations.
Pregnancy & Lactation
- Pregnancy: Not recommended as its safety during pregnancy is not established.
- Lactation: Dinogest is excreted in breast milk. Consider discontinuing breastfeeding or the medication based on the benefit-risk assessment.
Precautions & Warnings
Ensure pregnancy is excluded before starting Dinogest. Use nonhormonal contraception if needed. Be cautious with hepatic impairment and understand that Dinogest may alter menstrual bleeding patterns.
Use in Special Populations
- Children: Not recommended for use before menarche; safety in adolescents has not been established.
- Elderly: Not indicated for use in the elderly.
Overdose Effects
No significant acute adverse effects noted with overdose; no specific antidote required.
Therapeutic Class
Female Sex Hormones
Storage Conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.
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