Dexonex 0.5

Indications

Allergic Conditions: Aids in managing severe allergic conditions resistant to standard treatments. These encompass asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, and serum sickness.

Collagen Diseases: Provides relief for collagen diseases such as lupus erythematosus and rheumatoid arthritis.

Dermatologic Diseases: From bullous dermatitis herpetiformis to severe erythema multiforme (Stevens-Johnson syndrome), offers solutions for various dermatologic ailments.

Endocrine Disorders: Helps manage primary or secondary adrenocortical insufficiency, congenital adrenal hyperplasia, hypercalcemia linked with cancer, and nonsuppurative thyroiditis.

Gastrointestinal Diseases: Conditions like regional enteritis and ulcerative colitis find relief through treatments.

Hematologic Disorders: Addresses acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia (Diamond-Blackfan anemia), idiopathic thrombocytopenic purpura, and selected cases of secondary thrombocytopenia.

Neoplastic Diseases: Assists in managing leukemias and lymphomas.

Nervous System Disorders: Offers solutions for acute exacerbations of multiple sclerosis, cerebral edema associated with primary or metastatic brain tumors, craniotomy, or head injuries.

Ophthalmic Diseases: From temporal arteritis to uveitis, addresses ocular inflammatory conditions unresponsive to topical corticosteroids.

Renal Diseases: Aids in inducing diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus.

Respiratory Diseases: Conditions such as berylliosis, pulmonary tuberculosis, idiopathic eosinophilic pneumonias, and symptomatic sarcoidosis find relief through treatments.

Rheumatic Disorders: Serves as adjunctive therapy for acute episodes or exacerbations in various rheumatic conditions like acute gouty arthritis, rheumatoid arthritis, and psoriatic arthritis.

Miscellaneous: Also supports in diagnostic testing and management of conditions like trichinosis and tuberculous meningitis.

Pharmacology

Dexamethasone, a synthetic glucocorticoid, reduces inflammation by inhibiting leukocyte migration and reversing increased capillary permeability while suppressing the immune response.

Dosage & Administration

Dosages are tailored to individual needs and responses. Recommends starting with the lowest effective dose for chronic conditions and adjusting as necessary.

For tablets, adult dosages range from 1 mg to 10 mg daily, while children’s dosages range from 0.03 mg/kg to 0.20 mg/kg. Higher doses may be temporarily required in some cases, but dosage reduction is encouraged as soon as possible.

For injections, offers intravenous, intramuscular, or local administration options. Dosages depend on severity and response, with careful consideration for each patient’s needs.

Interaction

Advises caution when using dexamethasone alongside certain medications, including diuretics, antidiabetics, non-steroidal anti-inflammatory drugs, oral anticoagulants, and liver enzyme-inducing drugs.

Contraindications

Discourages the use of dexamethasone in cases of gastric and duodenal ulcers, systemic and ophthalmic fungal infections, viral infections, glaucoma, and hypersensitivity to corticosteroids.

Side Effects

Acknowledges potential adverse reactions associated with prolonged systemic glucocorticoid therapy and recommends close monitoring for various side effects.

Pregnancy & Lactation

Advises caution in the use of corticosteroids during pregnancy and lactation, recommending their use only when the potential benefits outweigh the risks.

Precautions & Warnings

Emphasizes the importance of using the lowest effective dose for corticosteroid therapy, with gradual dosage reduction when possible. Special precautions are advised for patients with certain conditions.

Use in Special Populations

Suggests titrating pediatric patients to the lowest effective dose to minimize potential growth effects.

Overdose Effects

While overdosage is unlikely, recommends supportive and symptomatic therapy if needed.

Storage Conditions

For optimal storage, advises keeping tablets in a cool, dry place protected from light and moisture and ensuring injections are stored appropriately.