Coufix

Indications

Coufix is recommended for alleviating:

• Chest congestion
• Cough
• Sore throat

Take this medication as directed by a registered physician.

Composition

Each 5 ml of Coufix syrup contains:

• Guaifenesin BP: 200 mg
• Dextromethorphan Hydrobromide BP: 15 mg
• Menthol USP: 15 mg

Pharmacology

Guaifenesin acts as an expectorant, helping to loosen mucus in the chest and throat, enabling easier expulsion through coughing.
Dextromethorphan Hydrobromide is a cough suppressant that reduces brain signals triggering the cough reflex.
Menthol is derived from mint oils or synthesized, providing local anesthetic and counter-irritant properties to soothe throat irritation.

Dosage & Administration

• Adults (12 years and older):
  • Take 2 teaspoons (10 ml) every 6 hours.
  • Do not exceed 8 teaspoons (40 ml) in a 24-hour period.
• Children under 12 years: Not recommended.

Always consult a registered physician before use.

Drug Interactions

Coufix may interact with the following:

• Acetaminophen or hydrocodone
• Diphenhydramine
• Escitalopram
• Alprazolam
• Ondansetron

Contraindications

• Do not use Coufix if you are currently taking or have recently stopped (within 2 weeks) a monoamine oxidase inhibitor (MAOI).
• Consult your doctor or pharmacist if unsure about MAOI interactions.

Possible Side Effects

Common side effects may include:

• Drowsiness or dizziness
• Gastrointestinal disturbances
• Nervousness, restlessness, or irritability

Pregnancy & Lactation

• Both Dextromethorphan Hydrobromide and Guaifenesin are classified under pregnancy category C by the FDA. Use during pregnancy should only occur if benefits outweigh the risks.
• Insufficient data exists regarding excretion in breast milk. Nursing mothers should consult a physician before use.
• There is no conclusive evidence on the safety of Menthol during pregnancy.

Precautions & Warnings

Consult a healthcare provider if you:

• Have asthma, chronic lung conditions, or persistent coughs.
• Are taking medications for depression, including MAOIs.

Overdose Effects

• Guaifenesin: Overdose is unlikely to cause severe toxicity. In extreme cases, gastric emptying may be necessary.
• Dextromethorphan Hydrobromide: Overdose symptoms include excitement, mental confusion, and respiratory depression at very high doses.
• Menthol: High doses may lead to nausea, vomiting, abdominal pain, dizziness, or rapid breathing.

Therapeutic Class

• Combined Cough Expectorants
• Combined Cough Suppressants

Storage Instructions

• Store below 30°C in a cool, dry place, away from direct light.
• Keep out of reach of children.