Contilex

Indications

This supplement is recommended for managing osteoarthritis affecting various joints including the knee, hip, spine, hand, and other areas. It also offers benefits in rheumatoid arthritis, sports injuries, migraines, skin conditions like psoriasis, vascular issues such as atherosclerosis, kidney stones, and inflammatory bowel diseases like ulcerative colitis and leaky gut syndrome.

Pharmacology

Glucosamine, a natural amino-sugar, is vital for the body’s production of glycosaminoglycans (GAGs) like Hyaluronic Acid, Keratan Sulfate, and Chondroitin Sulfate, crucial components of joint cartilage. Introducing Glucosamine Sulfate supplementation helps boost Glucosamine levels in the body, aiding in cartilage repair. Additionally, it stimulates chondrocytes, which support GAGs and proteoglycan production.

Chondroitin Sulfate, another essential component, works similarly to Glucosamine Sulfate by providing substrates for proteoglycan synthesis and safeguarding existing cartilage from degradation.

Combination Benefits

Combining Glucosamine with Chondroitin Sulfate yields synergistic effects. Research supports their efficacy in treating severe osteoarthritis symptoms and modifying disease progression. This combination also helps prevent osteoarthritis and offers relief comparable to NSAIDs but with better tolerability and clinical compliance. Moreover, it aids in soft tissue injury repair.

Dosage & Administration

The recommended dosage varies based on body weight and can be adjusted according to individual response. Typical dosages include:

• Under 54 kg: 1000 mg Glucosamine Sulfate & 800 mg Chondroitin Sulfate per day
• 54 kg to 91 kg: 1500 mg Glucosamine Sulfate & 1200 mg Chondroitin Sulfate per day
• Over 91 kg: 2000 mg Glucosamine Sulfate & 1600 mg Chondroitin Sulfate per day.

Interaction

There have been no significant reports of drug interactions with Glucosamine and Chondroitin, except for potential enhancement of blood thinning effects with anticoagulants like Warfarin and Heparin.

Contraindications

While there are no known contraindications, individuals with proven hypersensitivity to shellfish or sulfur should avoid Glucosamine and Chondroitin supplements.

Side Effects

Safety studies have shown no demonstrable side effects. Rare occurrences, such as mild and reversible intestinal flatulence, are minimal and akin to placebo effects.

Pregnancy & Lactation

Pregnant or potentially pregnant women should avoid supplementation due to insufficient studies on fetal effects. There’s limited data on use during lactation, so caution and medical advice are recommended.

Precautions & Warnings

Patients with Diabetes Mellitus should monitor blood glucose levels regularly. While no specific studies exist for renal or hepatic insufficiency, caution is advised, especially in severe cases. Children should not use these supplements.

Therapeutic Class

This supplement falls under the category of cartilage formation stimulation.

Storage Conditions

Store in a cool, dry place away from light.