Clopramin 25

Indications

Clopramin is prescribed for the treatment of:

• Obsessive-Compulsive Disorder (OCD)
• Major Depressive Disorder (MDD)
• Depression

Always use this medication as directed by a registered healthcare professional.

Pharmacology

Clopramin, containing Clomipramine Hydrochloride, is a tricyclic antidepressant (TCA) from the dibenzazepine class. This medication primarily works by influencing the serotonergic transmission in the brain, which plays a key role in managing obsessive and compulsive behaviors. While the exact neurochemical mechanism is not fully understood, it is believed that Clopramin inhibits the reuptake of serotonin (5-HT), helping alleviate symptoms such as obsessions and compulsions, and improving social interactions.

Dosage

• Initial Dose: Start with 25 mg at bedtime for approximately one week.
• Gradual Dose Increase: Do not exceed 150 mg per day for adults and 75 mg per day for elderly patients.
• The dose may be divided into smaller doses to reduce gastrointestinal disturbances.
• Not recommended for use in children.
  Always consult your healthcare provider before starting or adjusting your medication.

Administration

• Swallow the capsules whole with a glass of water.
• Continue taking the medication as prescribed, even if you start feeling better. Clopramin may take up to 4 weeks to show full effects.
• The medicine can be taken as a single dose at night or in divided doses throughout the day.
  Always follow your doctor’s instructions for use.

Drug Interactions

Be cautious when using Clopramin with other medications, especially those used to treat depression, such as:

• MAOIs (e.g., tranylcypromine, phenelzine, moclobemide)
• SSRIs (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline)
• SNaRIs (e.g., venlafaxine)
• Other antidepressants (e.g., amitriptyline, dothiepin, maprotiline)
• Diuretics (e.g., bendroflumethiazide, furosemide)
• Anesthetics and Beta blockers
• Blood pressure medications and Anticoagulants

Always inform your doctor about all the medications you are taking to prevent potential interactions.

Contraindications

Clopramin should not be used by individuals who:

• Are hypersensitive to Clomipramine Hydrochloride or other tricyclic antidepressants in the dibenzazepine group
• Are in the acute recovery phase after a myocardial infarction
• Are taking or have recently taken Monoamine Oxidase Inhibitors (MAOIs) (within 14 days)

Common Side Effects

The most frequently reported side effects include:

• Gastrointestinal issues (e.g., nausea, constipation, dry mouth)
• Headache, dizziness, and tremors
• Difficulty urinating and changes in vision
• Fatigue, sleepiness, sexual disturbances, and restlessness

If any side effects persist or worsen, contact your doctor immediately.

Pregnancy & Lactation

• There are no well-controlled studies on the use of Clopramin during pregnancy.
• Limited data suggests that Clomipramine may be excreted in breast milk. It is not recommended for use during pregnancy due to potential risks to the fetus.

Precautions & Warnings

Consult your doctor before taking Clopramin if you:

• Have a history of suicidal thoughts or behaviors
• Suffer from epilepsy or have had a head injury
• Are scheduled for electroconvulsive therapy (ECT)
• Have heart issues, kidney disease, liver disease, or thyroid problems
• Suffer from a blood disorder or overactive thyroid
• Have experienced long-term constipation or have adrenal gland tumors
• Wear contact lenses or have low blood pressure

Overdose Effects

In case of an overdose, symptoms may include:

• Dry mouth, dilated pupils, coma, and convulsions
• Tachycardia, cardiac arrhythmia, respiratory depression, and fluctuating blood pressure

Seek immediate medical attention if overdose symptoms occur.

Therapeutic Class

Clopramin belongs to the Tricyclic Antidepressants (TCAs) and related antidepressant drugs.

Storage Instructions

• Store below 30°C, away from light, and out of reach of children.
• Keep the medication in its original container to protect it from moisture.