Clinface

Indications

Clindamycin and Tretinoin gel effectively treats Acne vulgaris through topical application.

Pharmacology

This gel combines the lincosamide antibiotic Clindamycin phosphate with the retinoid Tretinoin. Clindamycin targets susceptible bacteria by binding to the 50s ribosomal subunit, suppressing bacterial protein synthesis and inhibiting Propionibacterium acne activity. Tretinoin enhances follicular epithelial cell turnover, reducing comedone formation.

Dosage & Administration

Before bedtime, gently wash the face with mild soap and water, then apply the gel using fingertips. In the morning, apply sunscreen after the gel application. Limit face washing to 2 or 3 times a day and use sunscreen as needed.

Safety and Effectiveness

Not established for children under 12 years old.

Interaction

Exercise caution with concomitant use of potentially irritating topical products. Avoid using Clindamycin with Erythromycin or neuromuscular medicine simultaneously.

Contraindications

Avoid use in individuals hypersensitive to Clindamycin, Tretinoin, or any other gel component.

Side Effects

Common side effects include erythema, scaling, dry skin, cough, sinusitis, and diarrhea.

Pregnancy & Lactation

Exercise caution when applying to nursing mothers; excretion in human milk is unknown.

Precautions & Warnings

Avoid application to eyes, nose, ears, lips, cuts, burns, or infections. After application, avoid sunlight exposure.

Therapeutic Class

Belongs to the topical antibiotic & retinoid preparations class.

Storage Conditions

Store below 25°C, away from light and moisture, and keep out of children’s reach.