Calcitrol 0.25

Indications

Calcitrol serves various purposes, including:

• Management of post-menopausal osteoporosis
• Treatment of renal osteodystrophy
• Support for postsurgical hypoparathyroidism
• Addressing idiopathic and pseudohypoparathyroidism
• Alleviating secondary hyperparathyroidism in patients with moderate to severe chronic renal failure (pre-dialysis)
• Management of vitamin D dependent rickets

Pharmacology

Calcitriol, a vital active metabolite of vitamin D3, plays a crucial role in calcium regulation and bone mineralization. It enhances calcium absorption in the intestines and regulates bone formation by stimulating osteoblastic activity.

Dosage & Administration

The appropriate dosage of Calcitriol capsules should be determined based on individual serum calcium levels. For instance:

• Post-menopausal osteoporosis: Recommended dosage is 0.25 mcg twice daily.
• Renal osteodystrophy: Initial dose is 0.25 mcg daily, adjusted based on calcium levels.
• Hypoparathyroidism and rickets: Initial dosage is 0.25 mcg/day, adjusted as needed.

For intravenous administration, the initial dose depends on the severity of the condition.

Interaction

Co-administration with thiazide diuretics increases the risk of hypercalcemia. Caution is necessary when using Calcitrol alongside digitalis, as it may precipitate cardiac arrhythmias. Magnesium-containing drugs may lead to hypermagnesemia.

Contraindications

Calcitriol is contraindicated in patients with known hypersensitivity to its components and in conditions associated with hypercalcemia.

Side Effects

Common side effects include weakness, headache, nausea, and bone pain. Long-term effects may include polyuria, anorexia, and hyperthermia.

Pregnancy & Lactation

Calcitriol usage during pregnancy should be carefully weighed against potential risks to the fetus. Breastfeeding mothers can use Calcitriol, but monitoring of calcium levels is advised.

Precautions & Warnings

Excessive dosage may lead to hypercalcemia. Caution is advised in patients on digitalis. Discontinuation should be gradual to avoid rebound effects.

Use in Special Populations

Dosage adjustments may be needed for pediatric and elderly patients.

Overdose Effects

Overdose may result in hypercalcemia and hyperphosphatemia. Treatment involves discontinuation and dietary adjustments.

Therapeutic Class

Calcitriol falls under the category of vitamin D preparations for bone health.

Storage Conditions

Store in a dry place away from light and heat, out of reach of children.